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Partial characterization of the cross-reacting determinant, a carbohydrate epitope shared by decay accelerating factor and the variant surface glycoprotein of the African Trypanosoma brucei



Partial characterization of the cross-reacting determinant, a carbohydrate epitope shared by decay accelerating factor and the variant surface glycoprotein of the African Trypanosoma brucei



Journal of Immunology 140(6): 2046-2050



The carboxyl terminal portion of the variant surface glycoprotein (VSG) of African trypanosomes contains a cryptic carbohydrate epitope, the cross-reacting determinant (CRD), that is revealed only after removal of the diacylglycerol by phosphatidylinositol-specific phospholipase C (PIPLC) or VSG lipase. It has been shown that after hydrolysis by PIPLC, decay-accelerating factor (DAF), a mammalian phosphatidylinositol-anchored protein, also contains the CRD epitope.

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Accession: 001904652

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PMID: 2450138


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