Persistence of colostral antibodies against virus-infection-associated (VIA) antigen and virus neutralizing antibodies induced by natural infection with foot-and-mouth disease virus in Indian buffalo (Bubalus bubalus) calves

Samara, S.I.; Pinto, A.A.; Abuhad, T.G.; Koseki, I.; Goncalves, E.I.; Mano Filho, A.C.

Revista da Faculdade de Medicina Veterinaria e Zootecnia da Universidade de Sao Paulo 24(1): 35-40


Accession: 001907347

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Antibody against virus-infection-associated (VIA) antigen and neutralizing serum antibody to foot and mouth disease virus was studied in 32 non-vaccinated Indian buffalo calves in Gusolandia, Sao Paulo, Brazil. Antibody levels against VIA antigen were detected by double immunodiffusion in 76.5% of the animals at 2.5 -3.5, 30% at 3.5-4.5, and 6.2% at 4.5-5.5 months of age. Antibody was no longer detectable at 6.5-9.5 months of age. Neutralizing serum antibody levels were studied in 12 of 32 animals. At 2.5-3.5 months of age neutralizing serum antibody for 01, A24 and C3 virus was found, respectively, in 83.3%, 83.3% and 66.6% of samples. At 4.5-5.5 months of age neutralizing serum antibody was present against the three types in only 20% of the animals and was no longer detected at 6.5-7.5 months. Twenty-one days after an outbreak in cattle, when the buffalo calves were 11.5-12.5 months old, antibody against VIA antigen was again detected in 20 of 32 (62.5%) of the animals. Neutralizing serum antibody was found in up to 63.3% of animals against type A24 and 16.6% against types 01 and 03.