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Substituted 5-phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines. Antifungal activity and structure-activity relationship studies



Substituted 5-phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines. Antifungal activity and structure-activity relationship studies



Annals of the New York Academy of Sciences 544: 359-362



A series of novel 5-phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines was prepared and tested in vitro for antifungal activity in broth and agar cultures. Although antifungal activity was evident throughout the series, in general, compounds having halogen(s) in either or both phenyl rings demonstrated the highest potency, especially against Trichophyton rubrum and Candida albicans. Overall, the dichloro derivative PR-967-248 was shown to possess the most useful antifungal activity.

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Accession: 001959501

Download citation: RISBibTeXText

PMID: 3214075

DOI: 10.1111/j.1749-6632.1988.tb40422.x



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