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Symptomatic selenium deficiency in a child on home parenteral nutrition

, : Symptomatic selenium deficiency in a child on home parenteral nutrition. Journal of Pediatric Gastroenterology and Nutrition 7(5): 783-786

A girl 27 months old with microvillous atrophy who was maintained on long-term home parenteral nutrition presented with regression of walking skills. She had a tender skeletal myopathy affecting both legs only. Plasma selenium was less than 0.05 mu mol/litre (normal 0.8 to 1.6 mu mol/litre), red blood cell glutathione peroxidase was undetectable, and plasma glutathione peroxidase was 6 U/litre (normal 90 to 350 U/litre).

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Accession: 001962204

PMID: 3141605

DOI: 10.1097/00005176-198809000-00029

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Related references

Kelly D.; Shenkin A.; Coe A.; Walker Smith J.A., 1987: Symptomatic selenium deficiency in a child on home parenteral nutrition hpn. Pediatric Research 22(1): 110

Fleming, C.R.; Lie, J.T.; McCall, J.T.; O'Brien, J.F.; Baillie, E.E.; Thistle, J.L., 1982: Selenium deficiency and fatal cardiomyopathy in a patient on home parenteral nutrition. An adult patient with chronic idiopathic intestinal pseudo-obstruction maintained on home parenteral nutrition for 6 consecutive years died from cardiomyopathy and ventricular fibrillation. Postmortem examination of the heart revealed widespread m...

Cohen, H.J.; Brown, M.R.; Hamilton, D.; Lyons-Patterson, J.; Avissar, N.; Liegey, P., 1989: Glutathione peroxidase and selenium deficiency in patients receiving home parenteral nutrition: time course for development of deficiency and repletion of enzyme activity in plasma and blood cells. The time course for the depletion of red blood cell (RBC) and plasma glutathione peroxidase (GSHPx) activity in five patients receiving home parenteral nutrition was documented. During the development of the RBC GSHPx deficiency, enzymatic activit...

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Quercia, R.A.; Korn, S.; O'Neill, D.; Dougherty, J.E.; Ludwig, M.; Schweizer, R.; Sigman, R., 1984: Selenium deficiency and fatal cardiomyopathy in a patient receiving long-term home parenteral nutrition. Fatal cardiomyopathy in a patient who received home parenteral nutrition (HPN) for eight years is reported, and the relationship of selenium deficiency to cardiomyopathy and other adverse effects is discussed. A 42-year-old white man with Crohn&ap...

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Baker, S.; Lerman, R.1; Krey, S.1; Crocker, K.1; Hirsh, E., 1983: Selenium deficiency with total parenteral nutrition: reversal of biochemical and functional abnormalities by selenium supplementation: a case report Erythrocyte glutathione peroxidase deficiency. American journal of clinical nutrition 38(5): 769-774

Rannem, T.; Ladefoged, K.; Hylander, E.; Hegnhøj, J.; Jarnum, S., 1993: Selenium depletion in patients on home parenteral nutrition. The effect of selenium supplementation. Severe selenium (Se) depletion was found in nine patients receiving long-term home parenteral nutrition because of short bowel syndrome. Plasma Se ranged from 0-0.51 (median 0.21 mumol/L), and erythrocyte Se ranged from 0.7-2.6 (median 1.8 mumol/g...

Etani, Y.; Nishimoto, Y.; Kawamoto, K.; Yamada, H.; Shouji, Y.; Kawahara, H.; Ida, S., 2015: Selenium deficiency in children and adolescents nourished by parenteral nutrition and/or selenium-deficient enteral formula. The authors analyzed serum selenium levels of 95 children and adolescents with intestinal dysfunction and/or neurological disabilities [age range: 7 months-20 years; mean±standard deviation (SD): 8.0±5.3 years] who received parenteral nutrition...

Baker S.S.; Lerman R.H.; Krey S.H.; Crocker K.S.; Hirsh E.F.; Cohen H., 1983: Selenium deficiency with total parenteral nutrition reversal of biochemical and functional abnormalities by selenium supplementation a case. American Journal of Clinical Nutrition 38(5): 769-774