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Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives


, : Synthesis and anthelmintic activity of a series of pyrazino[2,1-a][2]benzazepine derivatives. Journal of Medicinal Chemistry 32(9): 2058-2062

The synthesis and structure-activity relationships of a series of 1,2,3,4,6,7,8,12b-octahydropyrazinoenzazepine derivatives are described. Many of these compounds were active in vitro against Taenia crassiceps.

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Accession: 001962409

PMID: 2769679

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Brewer M.D.; Burgess M.N.; Dorgan R.J.J.; Elliott R.L.; Mamalis P.; Manger B.R.; Webster R.A.B., 1989: Synthesis and anthelmintic activity of a series of pyrazino 2 1 a 2 benzazepine derivatives. A series of 1,2,3,4,6,7,8,12b-octahydropyrazino[2,1-a][2]benzazepine derivatives was prepared and the cestocidal activity of the compounds evaluated in an in vitro Taenia crassiceps screen. Many of these derivatives proved to be highly active, and...

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