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Synthesis of 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-(2-chloro-4-trifluoromethylphenoxy)phenyl)urea






Journal of Labelled Compounds and Radiopharmaceuticals 27(12): 1409-1413

Synthesis of 1-(2,6-difluorobenzoyl)-3-(2-fluoro-4-(2-chloro-4-trifluoromethylphenoxy)phenyl)urea

The synthesis of radiolabelled flufenoxuron, a potent new acylurea insecticide and acaricide, is described.


Accession: 001962521



Related references

Gillam M.G., 1989: Synthesis of 1 2 6 difluorobenzoyl 3 2 fluoro 4 2 chloro 4 trifluoromethylphenoxy ring uniformly carbon 14 labelled phenylurea. 1-(2,6-Difluorobenzoyl)-3-(2-fluoro-4-(2-chloro-4-trifluoromethylphenoxy) [ring-U-14C]phenyl)urea, a potent new acylurea insecticide and acaricide known as flufenoxuron, was labelled with carbon-14 starting from o-dinitro[ring-U-14C]benzene 1. 2-F...

Bergman A.; Wachtmeister C.A., 1977: Synthesis of carbon 14 bi phenyl and of some chlorinated carbon 14 bi phenyls containing 4 chloro phenyl 2 4 di chloro phenyl and 2 3 6 tri chloro phenyl nuclei from the corresponding labeled anilines. Chemosphere 6(11): 759-767

Anthony, L.E.; Jones, A.L., 1977: Influence of 2-acetoamidoethyl (p-chloro-phenyl) (m-trifluoromethylphenoxy) acetate (halofenate) on hepatic drug metabolism in retired breeder rats. Chronic administration of halofenate at 2 dose levels (30 and 60 mg/kg) to male retired breeder rats caused a significant lowering of serum cholesterol levels. Halofenate treatment also produced hepatomegaly in rats, and this increase in liver wei...

Sundstrom G., 1973: Poly chlorinated bi phenyls part 4 synthesis of 2 2 3 3 4 4 5 6 octa chloro bi phenyl carbon 14 from 3 nitro 2 2 3 4 4 5 6 hepta chloro bi phenyl carbon 14 and tetra chloro methane. Acta Chemica Scandinavica: 1109-1111

Halpaap K.; Horning E.C.; Horning M.G., 1978: Comparison of the metabolism of bi phenyl 4 chloro bi phenyl and 4 fluoro bi phenyl. Toxicology & Applied Pharmacology 45(1): 237-238

Loh, W-Sin.; Fun, H-Kun.; Sarveswari, S.; Vijayakumar, V.; Reddy, B.Palakshi., 2010: 6-Chloro-3-[5-(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4-phenyl-quinoline. In the title compound, C(31)H(23)ClFN(3), the pyrazole ring forms dihedral angles of 72.75 (7), 18.08 (9) and 86.26 (9)° with the quinoline ring system, the phenyl ring and the fluoro-phenyl ring, respectively. In the crystal, inter-molecul...

Abdel-Wahab, B.F.; Ng, S.Weng.; Tiekink, E.R.T., 2013: 2-[3-(4-Chloro-phen-yl)-5-(4-fluoro-phenyl)-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thia-zole. In the title compound, C24H17ClFN3S, the pyrazole ring is almost planar (r.m.s. deviation = 0.030 Å). With the exception of the methine-bound benzene ring, which forms a dihedral angle of 85.77 (13)° with the pyrazole ring, the remaining non...

Chen, L.; Ou, X-Ming.; Mao, C-Hui.; Shang, J.; Huang, R-Qiu.; Bi, F-Chun.; Wang, Q-Min., 2007: Synthesis and bioassay evaluation of 1-(4-substitutedideneaminooxymethyl)-phenyl-3-(2,6-difluorobenzoyl)ureas. A variety of novel 1-(4-substitutedideneaminooxymethyl)-phenyl-3-(2,6-difluorobenzoyl)ureas were designed and synthesized by the reaction of 4-substitutedideneaminooxyrnethyl aniline with 2,6-difluorobenzoyl isocyanates in good yields. The title...

Ernst W.; Goerke H.; Weber K., 1977: Fate of carbon labeled di chloro bi phenyl tri chloro bi phenyl and penta chloro bi phenyl in the marine annelid nereis virens part 2 degradation and fecal elimination. Chemosphere 6(9): 559-568

Forlin, L.; Lidman, U., 1978: Effect of clophen a 50 4 chloro bi phenyl 2 5 2 5 tetra chloro bi phenyl and 2 4 5 2 4 5 hexa chloro bi phenyl on the mixed function oxidase system of rainbow trout salmo gairdneri liver. Clophen A50 and 2,4,5,2',4',5'-hexachlorobiphenyl enhanced the O-demethylation of p-nitroanisole to p-nitrophenol and the content of cyt [cytochrome] P-450 in the rainbow trout liver. Dose dependence in relation to time of the induc...