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Synthesis of macrocyclic trichothecene mycotoxins


Tetrahedron 45(8): 2385-2416
Synthesis of macrocyclic trichothecene mycotoxins
In the first part synthetic approaches and total syntheses of the trichothecenes are summarized. Special attention is paid to not naturally occurring derivatives of the sesquiterpenoids. In the second part the syntheses of macrocyclic trichothecenes are reviewed, with special reference to the preparation of the macrolidic building blocks, protecting groups and methods of macrolactonization. The preparation of several new unnatural macrocyclic analogues is reported. Finally the biological activity of the simple and macrocyclic trichothecenes are briefly discussed.

Accession: 001962587

DOI: 10.1016/s0040-4020(01)83438-4

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