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Synthesis of trypanosome hsp70 mRNA is resistant to disruption of trans-splicing by heat shock


, : Synthesis of trypanosome hsp70 mRNA is resistant to disruption of trans-splicing by heat shock. Journal of Biological Chemistry 264(13): 7107-7110

Synthesis of mRNA in trypanosomes involves an apparent trans-splicing reaction whereby a common 39-nucleotide mini-exon sequence is joined to the protein-coding exon of a mRNA precursor. It was previously shown that the trans-splicing pathway of Trypanosoma brucei is sensitive to disruption by severe heat shock. The synthesis of heat shock protein 70 (hsp70) mRNA in T. brucei is apparently resistant to the heat-induced disruption of splicing.

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Accession: 001962646

PMID: 2708359

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