+ Translate

T cell phenotype alterations in hepatosplenic schistosomiasis mansoni normalize after chemotherapy

, : T cell phenotype alterations in hepatosplenic schistosomiasis mansoni normalize after chemotherapy. Immunobiology 179(4-5): 342-352

Peripheral blood T cell phenotypes, CD3-induced mitogenesis and soluble IL 2 receptor and CD8 in sera were studied in intestinal and hepatosplenic Schistosomiasis mansoni before and three to six months after therpy with praziquantel. Fifteen pairs matched for intensity of infection were analyzed and compared with local, non-infected age-matched controls. CD3+ cell counts were lower in untreated hepatosplenic schistosomiasis (median 1040 cells/.mu.l; 95% confidence interval 608-1269) compared to controls (1534; 1264-1620). This difference was largely accounted for by immature CD1+/CD3-cells circulating in these patients (median 388/.mu.l, 252-474). The frequency of CD1+ T cells in circulation decreased drastically after chemotherapy. Similar, but less marked, alterations were seen in intestinal schistosomiasis. Lymphocyte proliferation initiated by agonistic anti-CD3 monoclonal antibody was severely impaired in hepatosplenic patients, who had suffered haemorrhagic complications, but not in the case of incipient hepatomegaly. Soluble CD8 antigen circulated in increased amounts in hepatosplenic schistosomiasis. Remarkably, a negative correlation between CD3-induced mitogenesis and circulating levels of CD8 was noted in these patients. Whereas CD3-induced mitogenesis in hepatosplenic schistosomiasis normalized after therapy, circulating IL 2R and CD8 antigen in hepatosplenic patients still exceeded control levels. The results demonstrate disturbances of CD3 and CD8 exression and/or T cell maturation in hepatosplenic schistosomiasis. Imbalanced CD4/CD8 ratios and an increased IL 2R/CD8 turnover may reflect an inhibitory circuit within the T cell compartment.

Accession: 001962947

PMID: 2515152

DOI: 10.1016/S0171-2985(89)80040-3

Download PDF Full Text: T cell phenotype alterations in hepatosplenic schistosomiasis mansoni normalize after chemotherapy

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Andrade, Z.A.; Cheever, A.W., 1971: Alterations of the intrahepatic vasculature in hepatosplenic schistosomiasis mansoni. Vinylite casts of intrahepatic vessels of cadavers with hepatosplenic schistosomiasis were made and compared with those of cadavers with normal livers and with cirrhosis of the liver. Extensive distortion and obstruction of small portal branches w...

Bogliolo, L., 1958: Anatomical bases of hepatosplenic schistosomiasis mansoni (the hepatosplenic form of schistosomiasis) & their clinical applications. Resenha Clinico-Cientifica 27(3-4): 86-93

Dimenstein, R.; Carvalho, V.C.; Oliveira, D.N.; Gillett, M.P., 1992: Alterations in the levels and lipid composition of plasma lipoproteins (VLDL, LDL and HDL) in Brazilian patients with hepatosplenic schistosomiasis mansoni. Plasma concentrations of low- and high-density lipoproteins (LDL and HDL) were significantly reduced in Brazilian patients, aged between 25 and 40 years and suffering with compensated hepatosplenic Schistosoma mansoni infections, when compared wit...

Gillett, M.P.; Sibrian, A.M.; Dimenstein, R.; Carvalho, V.C.; Gonçalves, M.M.; Chaves-Filho, M., 1989: Alterations in the fatty acyl composition of plasma cholesteryl esters in Brazilian patients with hepatosplenic schistosomiasis mansoni. Normal healthy individuals and patients suffering from hepatosplenic Schistosoma mansoni infection were compared for the fatty acyl compositions of circulating plasma cholesteryl esters and of those formed in vitro by the action of LCATase (lecith...

Drummond, S.Costa.; Pereira, P.Nunes.; Otoni, A.; Chaves, B.Assis.; Antunes, C.Maurício.; Lambertucci, Jé.Roberto., 2014: Thrombocytopenia as a surrogate marker of hepatosplenic schistosomiasis in endemic areas for Schistosomiasis mansoni. This study aimed to evaluate whether a low platelet count is a good surrogate marker of hepatosplenic schistosomiasis (HSS) in a rural area of Brazil. A small district in southeastern Brazil, with a population of 1,543 individuals and a 23% preval...

Helmy-Khalil, S.; Fahmy, M.H.; Ghanem, M.H.; Said, M.; E.S.wy, M.; Nofal, M.; Awadalla, H.N.; Youssef, M.; Mucke, D.; Brock, J., 1979: Cell mediated immune (CMI) responsiveness to soluble egg antigen (SEA) and its relation to the occurrence of schistosomal hepatosplenic disease in patients with schistosomiasis mansoni. The delayed intradermal test was positive for all 60 cases of Schistosoma mansoni examined using soluble egg antigen. The mean wheal area was significantly greater (3.7 plus or minus 2.0cm2) in the 40 patients with schistosomal hepatic fibrosis th...

Teixeira-Carvalho, A.; Martins-Filho, O.A.; Andrade, Z.A.; Cunha-Mello, J.R.; Wilson, R.A.; Correa-Oliveira, R., 2002: The study of T-cell activation in peripheral blood and spleen of hepatosplenic patients suggests an exchange of cells between these two compartments in advanced human Schistosomiasis mansoni infection. A histopathological and immunophenotypic study was performed on the spleen of patients with hepatosplenic (HS) schistosomiasis mansoni. Morphological data demonstrated that all HS patients presented features related to Schistosoma mansoni-induced...

Pittella, J.E., 1981: Hepatic encephalopathy in hepatosplenic schistosomiasis mansoni. Schistosoma mansoni, patients with hepatosplenic schistosomiasis, physiopathological disturbance of central nervous system secondary to severe hepatic infection, brief clinical discussion

Tanabe, M., 2003: Haemostatic abnormalities in hepatosplenic schistosomiasis mansoni. Hepatosplenic schistosomiasis is a complex immuno-regulatory disease and is major health problem in endemic countries. Acute bleeding is one of its most serious complications and often life-threatening. Clinical studies have demonstrated that the...

Warren, K.S., 1968: Pathophysiology and pathogenesis of hepatosplenic schistosomiasis mansoni. The clinical state, pathophysiology, pathology and pathogenesis of human and experimental hepato-splenic schistosomiasis mansoni are discussed.