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T lymphocyte subset modulation of hepatic fibroblast function in murine schistosomiasis


, : T lymphocyte subset modulation of hepatic fibroblast function in murine schistosomiasis. American Journal of Tropical Medicine and Hygiene 41(4): 454-459

We have previously shown that co-culture of T cell enriched spleen lymphocytes can reduce collagen synthesis and stimulate proliferative activity by liver fibroblasts from Schistosoma mansoni infected mice. The present study examines which subset of T cells is responsible for this modulation. Co-culture of fibroblasts with the total T cell population lead to significant stimulation in fibroblast proliferative activity and a significant decrease in the incorporation of 14C-proline into collagenase-sensitive protein. There was virtually no effect on total incorporation of 14C-proline in non-collagen proteins. An additional significant increase in fibroblast proliferative activity and another significant decrease in collagen synthesis accompanied by a 2-fold increase in non-collagen protein production was noted when fibroblasts were co-cultured with Lyt-1+ cells. Co-culture of fibroblasts with Lyt-2+ cells did not differ significantly from co-culture with total T cells. Mitomycin treatment of the lyphocytes blunted their specific effects, suggesting that proliferation of T cells is required for maximal exertion of their regulatory activity. These results suggest that the T cells which mediate these effects belong to the Lyt-1+ helper class and are distinct from the Lyt-2+ suppressor cells.

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Accession: 001962971

PMID: 2508503

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Gorelick, A.; Oglesby, T.; Rashbaum, W.; Atkinson, J.; Buyon, J. P., 1994: Ontogeny of complement regulatory proteins Discordant expression in the fetal heart. Clinical Research 42(2): 272A

Magomedmirzaev M.M.; Isaev G.I., 1986: Populational morphogenetic analysis of the fruit size and shape based on pear species. Populational analysis was used in a study of fruit organogenesis in Pyrus caucasica, P. salicifolium and Pyrus .times. Vsevolodia, collected from the central piedmont Dagestan ASSR, Russian SFSR, USSR. The dynamics of the variability indices of th...

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Kapur T.R.; Narula H.S.; Mohan M.N.; Misra M.S., 1981: Abo blood groups in vitiligo. ABO blood groups were determined in 100 cases of vitiligo and an equal number of controls among Indian Armed Forces personnel and their dependents. Statistically there was no significant difference.

Keung, W.M., 1995: Dietary estrogenic isoflavones are potent inhibitors of beta-hydroxysteroid dehydrogenase of P. testosteronii. The isoflavones daidzein, genistein, biochanin A and formononetin selectively inhibit the gamma-isozymes of mammalian alcohol dehydrogenase (ADH). Since gamma-ADH is the only ADH isoform that catalyzes 3 beta-hydroxysteroid oxidation, it was conje...

Havaux, M., 1991: Photosynthesis under environmental stresses Photoinhibition and photoprotection. De Kouchkovsky, Y [INRA Colloquia; Plant sciences today: First general colloquium on plant sciences] Colloques de l'INRA; Plant sciences today: First general colloquium on plant sciences : 225-226

Cunningham, B.A., 1995: Cell adhesion molecules as morphoregulators. Many significant advances have been made recently in our understanding of the structure and function of cell adhesion molecules (CAMs). The most provocative, however, are those that indicate that CAM-mediated adhesion may lead to changes in gene e...

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Carraher R.P.; Hahn D.W.; Mcguire J.L., 1981: Pharmacological selectivity of suprofen a new analgesic prostaglandin synthetase inhibitor. Federation Proceedings 40(3 PART 1): 280

Runge, C. F.; Myers, R. J., 1985: Shifting foundations of agricultural policy analysis: welfare economics when risk markets are incomplete. In this paper, we argue that an improved paradigm is being developed and that, while many problems of implementing policy analyses based on this paradigm remain, the approach shows considerable promise of shifting the foundations of agricultural...