EurekaMag.com logo
+ Translate

T-cell antigen receptor alpha chain polymorphisms in insulin-dependent diabetes


, : T-cell antigen receptor alpha chain polymorphisms in insulin-dependent diabetes. Journal of Autoimmunity 1(5): 389-397

BB rats develop a spontaneous T-cell mediated autoimmune diabetes. The diabetes has been linked in several breeding studies to an undetermined autosomal recessive gene causing T-cell lymphopenia.

Accession: 001962979

PMID: 2908175

DOI: 10.1016/0896-8411(88)90063-7

Download PDF Full Text: T-cell antigen receptor alpha chain polymorphisms in insulin-dependent diabetes


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Millward, B.A.; Welsh, K.I.; Leslie, R.D.; Pyke, D.A.; Demaine, A.G., 1987: T cell receptor beta chain polymorphisms are associated with insulin-dependent diabetes. We investigated the T cell receptor constant beta chain (TCR C beta) genes of patients with insulin dependent diabetes mellitus (IDDM) using DNA restriction fragment length polymorphism (RFLP) analysis. Genomic DNA from patients and controls was d...

Martínez-Naves, E.; Peña, M.; López-Larrea, C., 1993: T-cell receptor alpha, delta, and gamma chain genes in insulin-dependent diabetes mellitus. We have studied the genotypic, haplotypic, and allelic distribution of germline Restriction Fragment Length Polymorphism (RFLP) of T-cell receptor (Tcr) alpha, gamma, and delta loci in 75 insulin-dependent diabetes mellitus (IDDM) patients and 84...

Bhatia, E.; Jackson, R.A., 1993: T-cell antigen receptor gamma chain polymorphisms in type 1 diabetes. The T-cell antigen receptor gamma chain, in conjunction with the delta chain, forms a functional receptor on a small percentage of circulating T-cells. Using restriction enzymes Msp 1 and Stu 1, and a human gamma chain cDNA probe, pT gamma 1, freq...

Hitman, G.A.; Niven, M.J.; Festenstein, H.; Cassell, P.G.; Awad, J.; Walker-Smith, J.; Leonard, J.N.; Fry, L.; Ciclitira, P.; Kumar, P., 1987: HLA class II alpha chain gene polymorphisms in patients with insulin-dependent diabetes mellitus, dermatitis herpetiformis, and celiac disease. We have investigated DNA polymorphism of the class II alpha chain genes in HLA typed patients with insulin dependent diabetes mellitus (IDDM; n = 79), celiac disease (CD; n = 46), dermatitis herpetiformis (DH; n = 53), and controls (n = 86). Prefe...

Field, L.L.; Stephure, D.K.; McArthur, R.G., 1991: Interaction between T cell receptor beta chain and immunoglobulin heavy chain region genes in susceptibility to insulin-dependent diabetes mellitus. Despite some reports of an association between insulin-dependent diabetes mellitus (IDDM) and a BglII RFLP in the T cell receptor beta chain (TCRB) constant region, results of several recent studies, including our own, have failed to support such...

Field L.L.; Bech Hansen N.T.; Tobias R.; Mcarthur R.G., 1988: No association between t cell receptor beta chain rflp and insulin dependent diabetes mellitus. American Journal of Human Genetics 43(3 SUPPL): A214

Hoover M.L.; Angelini G.; Ball E.; Ferrara G.B.; Marks J.; Raskin P.; Rosenstock J.; Stastny P.; Tosi R.; Capra J.D., 1986: Insulin dependent diabetes mellitus is associated with polymorphic forms of the t cell receptor beta chain gene. Clinical Research 34(2): 725A

McMillan, S.A.; Graham, C.A.; Hart, P.J.; Hadden, D.R.; McNeill, T.A., 1990: A T cell receptor beta chain polymorphism is associated with patients developing insulin-dependent diabetes after the age of 20 years. We have studied the BglII polymorphism near the T cell receptor beta chain constant region (TcR-C beta) gene, HLA-DR genotypes and certain autoimmune features in 102 patients with type I (insulin-dependent) diabetes. There was a significant decrea...

Martínez-Naves, E.; Coto, E.; Gutiérrez, V.; Urra, J.M.; Setién, F.; Domínguez, O.; Hood, L.E.; López-Larrea, C., 1991: Germline repertoire of T-cell receptor beta-chain genes in patients with insulin-dependent diabetes mellitus. We have investigated the genotype and allelic distribution of germline restriction fragment length polymorphisms of the T-cell receptor beta chain, segment C beta, and two variable segments which are in linkage disequilibrium, V beta 8 and V beta...

Spielman R.S.; Cox N.J.; Sylvester D.R.; Concannon P., 1987: Segregation of t cell receptor beta chain rflps in sibs with insulin dependent diabetes mellitus iddm. American Journal of Human Genetics 41(3 SUPPL): A186