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T-cell antigenic sites of the malaria circumsporozoite protein


, : T-cell antigenic sites of the malaria circumsporozoite protein. Blood 74(3): 895-900

The importance of T-cells in immunity to Plasmodium sporozoites, and in the development of a malaria vaccine is dicussed under the headings: sporozoite immunity; CD4 T-cell activation; CD8 T-cell activation.

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Accession: 001962980

PMID: 2665866

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Dontfraid, F.; Cochran, M.A.; Pombo, D.; Knell, J.D.; Quakyi, I.A.; Kumar, S.; Houghten, R.A.; Berzofsky, J.A.; Miller, L.H.; Good, M.F., 1988: Human and murine CD4 T cell epitopes map to the same region of the malaria circumsporozoite protein: limited immunogenicity of sporozoites and circumsporozoite protein. The circumsporozoite (CS) protein is a candidate vaccine antigen for the sporozoite stage in the life cycle of the malaria parasite. Using CS protein purified from recombinant baculovirus-infected cells and a panel of H-2 congenic mice, we are abl...

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