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The effects of lactulose-sweetened yoghurt on the rate of gastric emptying and intestinal transit in healthy human volunteers



The effects of lactulose-sweetened yoghurt on the rate of gastric emptying and intestinal transit in healthy human volunteers



Zeitschrift fur Ernahrungswissenschaft 27(3): 150-154



A non-invasive, radioisotopic method was utilised to study the effects of a lactulose-sweetened yogurt product on gastric emptying and intestinal transit. Healthy human volunteers were given 99mtechnetium-DTPA-labelled lactulose yogurt before and after adaptation to the product. A control group received a similarly labelled glucose solution. Gastric emptying and intestinal transit were evaluated by scintigraphy. The mean half-time for gastric emptying for glucose was 39.8 .+-. 3.4 min and for lactulose yogurt, 31.3 .+-. 11.0 min. After 10 days' adaptation the corresponding value for lactulose yogurt was 25.2 .+-. 8.2 min. Intestinal transit time was faster after lactulose yogurt than after glucose solution and did not change during adaptation. The observed effects indicate that lactulose yogurt may be beneficial in the treatment or chronic constipation using dietary methods.

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Accession: 001974174

Download citation: RISBibTeXText

PMID: 3070971

DOI: 10.1007/bf02024719


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