The inhibitory action of zinc on gastric secretion and on stress-induced gastric ulceration in rats

Cho, C.H.; Ogle, C.W.

Trace substances in environmental health-21 Proceedings of the University of Missouri' s 21st Annual Conference on Trace Substances in Environmental Health, St Louis, MO, USA, 24-28 May 1987: 567-573


Accession: 001978586

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The effects of zinc deficiency, or of Zn administration to normal animals, on secretion and on cold-restraint stress-induced ulceration in rat stomachs were studied. Feeding with graded Zn-deficient diets significantly lowered serum Zn concentration and increased gastric secretion; it reduced the gastric glandular mast cell count and produced ulceration. Zn deficiency also aggravated stress-induced ulceration and mast cell degranulation in the gastric glandular mucosa. Zn sulphate pretreatment (22, 44 or 88 mg/kg intraperitoneally 48 h beforehand) increased serum Zn but reduced Zn gastric secretion in Zn-sufficient rats; it also prevented stress-induced ulceration and mast cell degranulation. It is concluded that the membrane-stabilizing action of Zn, especially on the mast cells, may regulate gastric secretion and prevent stress ulceration in rat stomachs.