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The lymphocyte system and the relative resistance of inbred mice to Trypanosoma brucei brucei



The lymphocyte system and the relative resistance of inbred mice to Trypanosoma brucei brucei



Annales de l' Institut Pasteur, Immunologie 139(5): 545-556



Seventy inbred CBA/Ca mice (subtolerant to T. brucei) and 60 inbred C3H/He mice (susceptible to T. brucei) were infected ip with 500 metacyclic trypanosomes (T. brucei EATRO 1125 AnTAR-1)/mouse. 40 CBA/Ca and 30 C3H/He were left uninfected as controls. In both strains trypanosomes were first detected in the peripheral blood of infected mice 5 days pi. Parasitaemia in C3H/He mice increased rapidly, reaching 10 x 108 trypanosomes/ml blood 24 days pi when the last mouse died.

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