+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Biochemical changes in rat lung during acute paraquat intoxication



Biochemical changes in rat lung during acute paraquat intoxication



Biomedical and Environmental Sciences 3(3): 343-352



Paraquat (PQ) was administered intraperitoneally to male Wistar rats at a dose of 30 mg/kg. This dose caused mortality in 14% of the animals and significantly increased the lung wet weight by 28 and 93% at 2 and 3 days after treatment, respectively, compared to controls. The activity of several enzymes present in the lung was affected by PQ treatment. Pulmonary angiotensin-converting enzyme activity was significantly reduced at 4 h after PQ treatment and remained 32-36% below control levels during the following 3-day observation period. Alkaline phosphatase activity in the lung was significantly decreased by 26-33% at 1, 2, and 3 days after PQ treatment. Lung glucose-6-phosphate dehydrogenase activity demonstrated a drop at 4 h, recovery to control levels at 1 day, and a subsequent rise to levels 45-55% higher than control levels at 2 and 3 days. Glutathione reductase activity in the lung decreased significantly by 21% at 2 and 3 days. These changes in enzyme activities, which may reflect effects on different cell populations of the lung and processes of damage and reparation, may prove to be useful as biochemical indicators of PQ toxicity.

(PDF emailed within 1 workday: $29.90)

Accession: 002036501

Download citation: RISBibTeXText

PMID: 2252554



Related references

Lung function in acute paraquat intoxication. Physiologia Bohemoslovaca 24(6): 559-563, 1975

Prolonged intravenous paraquat infusion in the rat 1. failure of coinfused putrescine to attenuate pulmonary paraquat uptake paraquat induced biochemical changes or lung injury. Toxicology and Applied Pharmacology 94(2): 207-220, 1988

Therapeutic hypothermia attenuates acute lung injury in paraquat intoxication in rats. Resuscitation 82(4): 487-491, 2011

The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication. Toxicology Letters, 2018

The activation of STIM1 mediates S-phase arrest and cell death in paraquat induced acute lung intoxication. Toxicology Letters 292: 123-135, 2018

The biochemical pathology of rat lung after acute paraquat poisoning. Toxicology & Applied Pharmacology: 485-486, 1973

Protective effects of N-acetylcysteine treatment post acute paraquat intoxication in rats and in human lung epithelial cells. Toxicology 223(3): 181-190, 2006

The time between paraquat ingestion and a negative dithionite urine test in an independent risk factor for death and organ failure in acute paraquat intoxication. Journal of Korean Medical Science 27(9): 993-998, 2013

Correlated biochemical and ultrastructural studies on the lung in isolated and combined acute treatment with ethanol and paraquat. Journal de Toxicologie Clinique et Experimentale 6(6): 353-368, 1986

Liver biochemical tests in paraquat intoxication. Changgeng Yi Xue Za Zhi 11(3): 160-166, 1988

Lung damage caused by paraquat. 1. Histologic, histochemical and pathophysiologic findings in rat lungs following acute paraquat poisoning. Zeitschrift für Erkrankungen der Atmungsorgane 167(1-2): 135-139, 1986

Single lung transplantation in paraquat intoxication. New York State Journal of Medicine 84(2): 82-84, 1984

Studies of lung damage by paraquat. 2. Effect of vitamin E on acute lung damage caused by paraquat. Zeitschrift für Erkrankungen der Atmungsorgane 169(2): 147-152, 1987

Acute Paraquat Intoxication. Chest Journal 116(3): 709-714, 1999

The clinical features of acute kidney injury in patients with acute paraquat intoxication. Nephrology, Dialysis, Transplantation 24(4): 1226-1232, 2008