Biochemical studies in Presbytis cristata infected with subperiodic Brugia malayi

Choong, M. F.; Mak, J. W.

The Presbytis cristata-Brugia malayi model, now established as a reliable non-human primate model for the experimental screening of potential filaricides, was monitored at monthly intervals for changes in the liver and renal function tests and also for alkaline phosphatase levels during infection. Animals infected with 200-400 infective larvae became patent at 50-90 days post-infection and geometric mean microfilarial counts were above 1000 per ml from the fourth month onwards.