EurekaMag.com logo
+ Site Statistics
References:
48,252,460
Abstracts:
22,798,453
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Can ethnopharmacology contribute to the development of antimalarial agents?


, : Can ethnopharmacology contribute to the development of antimalarial agents?. Journal of ethno pharmacology 32(1-3): 155-165

The resistance of Plasmodium falciparum, the cause of tertian malaria, to synthetic antimalarials, together with the resistance of the vector mosquitoes to insecticides, has resulted in a resurgence in the use of quinine and a search for new antimalarial agents. In recent years, artemisinin, isolated from Artemisia annua which is used in Chinese traditional medicine for the treatment of malaria, has proved to be effective in the treatment of cerebral malaria due to chloroquine-resistant strains of P. falciparum. The development of in vitro tests utilising P. falciparum obtained from malaria patients means that it is possible to use bioassay guided fractionation of active extracts in order to isolate active principles. A number of laboratories throughout the world are currently investigating plants used in traditional medicine for their active constituents. Some of their results will be described and in particular two aspects of our investigations with species of Simaroubaceae and Menispermaceae will be discussed. There is every possibility that such approaches which use leads from Ethnopharmacology will result in the development of new antimalarial agents. It is vitally important to those populations relying on traditional medicines for the treatment of malaria that the safety and efficacy of such medicines be established, their active principles determined and that reproducible dosage forms be prepared and made available for use.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 002042316

PMID: 1881153

DOI: 10.1016/0378-8741(91)90113-R

Download PDF Full Text: Can ethnopharmacology contribute to the development of antimalarial agents?


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Anonymous, 2003: Proceedings of the international conference on quality in chains, an integrated view on fruit and vegetable quality, Wageningen, Netherlands, 6-9 July, 2003. Volumes 1 and 2. This proceedings contains 106 papers dealing with aspects of crop produce quality throughout the supply chain; quality modelling and quality aspects relevant for consumer, provider and producer; effects of handling on quality; manipulation of qual...

Brude, I.R.; Drevon, C.A.; Hjermann, I.; Seljeflot, I.; Lund-Katz, S.; Saarem, K.; Sandstad, B.; Solvoll, K.; Halvorsen, B.; Arnesen, H.; Nenseter, M.S., 1997: Peroxidation of LDL from combined-hyperlipidemic male smokers supplied with omega-3 fatty acids and antioxidants. The effects of marine omega-3 polyunsaturated fatty acids (FAs) and antioxidants on the oxidative modification of LDL were studied in a randomized, double-blind, placebo-controlled trial. Male smokers (n = 41) with combined hyperlipidemia were all...

Natin, I.; D.R.n, C., 1935: Hy-pochloremia in diphtheria and its relation with azotemia. In 11 cases of diphtheria the blood Cl was below normal in the acute period. In a fatal case the amt. of Cl, though low, was higher than in the cases of recovery. In some cases the N and Cl became normal at about the same rate; in others the urea...

Babers, Frank H., 1955: The solubility of DDT in water determined radiometrically. Jour Amer Chem Soc: 4666

Earle, RA.; Bennett, GF.; Brossy, JJ., 1992: First African record of Leucocytozoon tawaki (Apicomplexa: Leucocytozoidae) fron the jackass penguin Spheniscus demersus. The occurrence of Leucocytozoon tawaki is recorded from blood smears of the jackass penguin Spheniscus demersus taken along the South African coast. These records represent both the first African specimens of this parasite as well as the first rec...

Israel, D.M.; Hassall, E., 1993: Treatment and long-term follow-up of Helicobacter pylori-associated duodenal ulcer disease in children. In a 7-year period, 33 children had endoscopically documented duodenal ulcer disease. Of the 33 children, 29 had Helicobacter pylori antral gastritis. All children with H. pylori-associated duodenal ulcer disease were treated with antibiotics but...

Nishikawa Y.; Hasegawa A.; Kakudo Y.; Koyama N.; Yokota T., 1989: Trigeminal nociceptive neurons in nonspecific thalamic nuclei of cat thalamus. Japanese Journal of Physiology 39(SUPPL): S125

Beste, D.F., 1968: An integrated pharmacist-nurse approach to the unit-dose concept. American Journal of Hospital Pharmacy 25(8): 397-407

Churchill, TB., 1991: A spiders secret tropical hideaway. Entomological Society of Queensland News Bulletin, 189: 107-108

Blatchford, W., 1996: Lease or purchase?. Dentistry Today 15(1): 80-80