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Cantharidin-induced acantholysis


American Journal of Dermatopathology 10(5): 419-423
Cantharidin-induced acantholysis
Cantharidin (0.1% in DMSO) was used to induce acantholysis by topical application to the forearms of volunteers. Intraepidermal clefting started at the junction between the basal and epidermal layers, and later involved all of the levels of the stratum spinosum. As a response to early acantholysis, an increased number of epibasal cells synthesized DNA. This was not related to an increased binding of epidermal growth factor to these cells.


Accession: 002042697

PMID: 3228189

DOI: 10.1001/archderm.1966.01600280127020



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