EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Dietary nucleotide effects upon immune function in infants



Dietary nucleotide effects upon immune function in infants



Pediatrics 88(2): 359-363



Nucleotide (NT) nitrogen, a component of nonprotein nitrogen, accounts for approximately 0.1% to 0.15% of the total nitrogen content of human milk. The results of studies in animals indicate that dietary NTs may be required for maintenance of normal immune function. Thirty-seven healthy term infants were either breast-fed (n = 9) or fed SMA formula supplemented with 33 mg of NTs per liter (n = 13, NT+) or standard SMA formula (n = 15; NT-). At 2 months of age, natural killer cell percent cytotoxicity was significantly higher in the breast-fed and NT+ groups compared with the NT- group (41.7 .+-. 4.7, 32.2 .+-. 3.4, 21.7 .+-. 2.2%, respectively). Interleukin-2 production by stimulated mononuclear cells was higher in the NT+ compared with the NT- group at 2 months of age (0.90 .+-. 0.28 U/ml, 0.27 .+-. 0.11 U/ml, respectively); neither formula-fed group differed significantly from the breast-fed group. Rate of growth and incidence and severity of infections did not differ significantly among dietary groups. Nucleotides may be a component of human milk that contribute to the enhanced immunity of the breast-fed infant.

(PDF 0-2 workdays service: $29.90)

Accession: 002072010

Download citation: RISBibTeXText

PMID: 1861940



Related references

Effect of dietary nucleotide supplementation on in vivo and in vitro immune function in protein-malnourished mice. 1995

Dietary fat and immune function. II. Effects on immune complex nephritis in (NZB x NZW)F1 mice. Journal of Immunology 135(6): 3864-3868, 1985

Dietary nucleotide effects on superior mesenteric artery blood flow in preterm infants. Pediatric Research 47(4 Part 2): 284A, April, 2000

Dietary nucleotide effects on superior mesenteric artery blood flow in term infants. Pediatric Research 47(4 Part 2): 284A, April, 2000

Effects of dietary nucleotide supplementation on growth performance and hormonal and immune responses of piglets. Animal 6(6): 902-908, 2012

Effects of early immune stress and changes in dietary metabolizable energy on the development of newly hatched turkeys. 2. Selected characteristics of immune function. Poultry Science 74(6): 998-1010, 1995

The effects of dietary selenium on immune function in healthy men. FASEB Journal 15(5): A969, March 8, 2001

Effects of dietary taurine on auditory function in full-term infants. Advances in Experimental Medicine and Biology 442: 507-514, 1998

Effects of dietary protein levels on the disease resistance, immune function and physical barrier function in the gill of grass carp (Ctenopharyngodon idella) after challenged with Flavobacterium columnare. Fish & Shellfish Immunology 57: 1-16, 2016

Effects of Lactobacillus acidophilus dietary supplementation on the performance, intestinal barrier function, rectal microflora and serum immune function in weaned piglets challenged with Escherichia coli lipopolysaccharide. Antonie van Leeuwenhoek 107(4): 883-891, 2016

Micronutrient deficiency and supplementation in Indonesian infants. Effects on immune function. Advances in Experimental Medicine and Biology 531: 369-377, 2003

Dietary supplementation with trans-11- and trans-12-18 : 1 increases cis-9, trans-11-conjugated linoleic acid in human immune cells, but without effects on biomarkers of immune function and inflammation. British Journal of Nutrition 97(6): 1196-1205, 2007

Effects of different dietary oil sources on immune function in cyclophosphamide immunosuppressed chickens. Animal Feed Science and Technology 139(3-4): 186-200, 2007

Effects of dietary antioxidants on the immune function of middle-aged adults. Proceedings of the Nutrition Society 58(1): 79-84, 1999