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Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation



Dietary nucleotide effects upon murine natural killer cell activity and macrophage activation



Jpen. Journal of Parenteral and Enteral Nutrition 14(1): 18-22



Weanling mice fed chow or chow plus water supplemented with 3.5 mg of nucleotides per 100 ml of water for 6 weeks exhibited increased natural killer cell (NK) activity and lower macrophage activiation compared to mice fed chow plus nonsupplemented water. In a dose-response study, NK activity, macrophage activation and spleen weight (as a percentage of body weight) were higher in mice fed up to 0.035% w/w nucleotides, however, macrophage activation was decreased by feeding over 0.35% w/w compared to those receiving basal purified diet (BPD). Nucleotides in human milk may affect the immune response in breast-fed infants.

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Accession: 002072011

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PMID: 2325242

DOI: 10.1177/014860719001400118



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