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Dietary restriction augments erythropoiesis in mice



Dietary restriction augments erythropoiesis in mice



International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift für Vitamin- und Ernahrungsforschung. Journal International de Vitaminologie et de Nutrition 60(4): 379-382



Previously, we have reported that a 40% dietary restriction caused microcytic and short-lived erythrocytes without anemia in mice (Internat. J. Vitr. Nutri. Res. (1989), 59, 406-412). To elucidate the mechanism of these phenomena, the effects of dietary restriction on the proliferation of erythroid precursor cells were investigated. In the diet restricted mice, a striking increase of erythropoietin (EP)-responsive erythroid precursor cells without increment of EP was observed. Remarkable increases in the numbers of femoral nucleated cells and erythroid stem cells (CFU-S) were also observed in the diet restricted mice. Furthermore, the percentage of femoral CFU-S in DNA synthetic stage (S phase) revealed remarkably higher levels in the diet restricted mice than in the control mice. Our results strongly suggest that the microcytic change of erythrocytes in the diet restricted mice may be attributed to the increased number of erythroid precursor cells without an increment of hemoglobin synthesis and that the avoidance of becoming anemic from the short-lived erythrocytes in the diet restricted mice may be caused by a vigorous erythropoiesis.

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Accession: 002072088

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PMID: 2101830



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