EurekaMag.com logo
+ Site Statistics
References:
53,869,633
Abstracts:
29,686,251
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Dietary sulfur amino acid modulation of cysteine sulfinic acid decarboxylase



Dietary sulfur amino acid modulation of cysteine sulfinic acid decarboxylase



American Journal of Physiology 261(5 Pt 1): E551-E555



Male rats were fed sulfur and nonsulfur amino acid-supplemented diets, and the response of cysteine sulfinic acid decarboxylase (CSAD) activity was determined. After adaptation to a casein-based basal diet, rats were fed diets containing additions of L-methionine. Hepatic CSAD activity decreased in a dose-dependent manner. Significant depression of CSAD activity in liver was evident within 24 h of feeding rats a methionine-supplemented diet. Depression of enzyme activity was reversed upon refeeding the basal diet. After rats were fed diets supplemented with methionine, cystine, homocystine, S-methyl-L-cysteine, phenylalanine, leucine, or ethionine for 14 days, hepatic CSAD activity in rats fed S-methyl-L-cysteine-, phenylalanine-, or leucine-supplemented diets was not depressed compared with activity in rats fed a basal diet. In contrast, CSAD activity in livers of rats fed cystine-, homocystine-, methionine-, or ethionine-supplemented diets was 60, 40, 40, and 8%, respectively, of the activity in livers from control rats. Immunochemical detection and quantification of CSAD protein in rat liver indicated that CSAD protein concentration was correlated to CSAD activity. CSAD activity may be specifically regulated by sulfur amino acids metabolized by the S-adenosylmethionine-dependent pathway of methionine metabolism.

(PDF emailed within 1 workday: $29.90)

Accession: 002072127

Download citation: RISBibTeXText

PMID: 1951678



Related references

Cysteine sulfinic acid decarboxylase mRNA is decreased in liver of rats fed sulfur amino acid supplemented diets. FASEB Journal 13(4 PART 1): A235, March 12, 1999

Measurement of excitatory sulfur amino acids, cysteine sulfinic acid, cysteic acid, homocysteine sulfinic acid, and homocysteic acid in serum by stable isotope dilution gas chromatography: Mass spectrometry and selected ion monitoring. Analytical Biochemistry 220(2): 249-256, 1994

Modulation of hepatic cysteine sulfinic acid decarboxylase activity csad by sulfur containing compounds. FASEB Journal 3(4): A1060, 1989

Comparison of regional distribution of l glutamate decarboxylase gamma amino butyric acid transferase cysteine sulfinic acid decarboxylase aspartate amino transferase and somatostatin in rat retina. Investigative Ophthalmology & Visual Science 22(3 SUPPL): 114, 1982

The distribution of taurine cysteine sulfinic acid decarboxylase and cysteine sulfinic acid alpha keto glutarate trans aminase in the rat olfactory bulb and olfactory nucleus. Neuroscience Letters 9(1): 59-64, 1978

Unusual sulfur containing amino acids in the urine of homo cystinuric patients part 3 homo cysteic acid homo cysteine sulfinic acid s carboxymethylthio homo cysteine and s 3 hydroxy 3 carboxy n propyl homo cysteine. Physiological Chemistry & Physics 4(3): 286-294, 1972

Hepatic cysteine sulfinic acid decarboxylase activity in rats fed various levels of dietary casein. Journal of Nutrition 119(11): 1593-1597, 1989

A new sulfinic amino acid: homohypotaureine (3-aminopropanesulfinic acid). Isolation, determination and chromatographic behaviour compared with sulfinic and sulfonic derivatives of cysteine and homocysteine. European Journal of Biochemistry 10(3): 569-573, 1969

Effects Of Reserpine And Chlorpromazine Hydrochloride On Brain Glutamic Acid Decarboxylase And Liver Cysteine Sulfinic Acid Decarboxylase. Bulletin de la Societe de Chimie Biologique 47: 719-722, 1965

Purification and characterization of cysteic acid and cysteine sulfinic acid decarboxylase and L-glutamate decarboxylase from bovine brain. Proceedings of the National Academy of Sciences of the United States of America 79(14): 4270-4274, 1982

Glutamic acid decarboxylase cysteine sulfinic acid decarboxylase activities and taurine biosynthesis in vivo. Neuroscience Letters Supplement: 68, 1985

Immunocytochemical localization of L-glutamate decarboxylase, gamma-aminobutyric acid transaminase, cysteine sulfinic acid decarboxylase, aspartate aminotransferase and somatostatin in rat retina. Brain Research 270(2): 273-283, 1983

Development of a novel cysteine sulfinic Acid decarboxylase knockout mouse: dietary taurine reduces neonatal mortality. Journal of Amino Acids 2014: 346809-346809, 2014

Immunocytochemical and autoradiographic methods to demonstrate the coexistence of neuroactive substance: cerebellar Purkinje cells have glutamic acid decarboxylase, cysteine sulfinic acid decarboxylase, and motilin immunoreactivity. Acta Morphologica Hungarica 31(1-3): 193-212, 1983