+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Dietary taurine content changes liver lipids in cats

Dietary taurine content changes liver lipids in cats

Journal of Nutrition 121(10): 1522-1528

Adult female cats were fed a completely defined purified diet (taurine-free) alone or containing 0.05% taurine (the normal dietary requirement) or 1% taurine (20-fold the normal dietary requirement) for greater than 2 y. The relative composition of conjugated biliary bile acids was not different among the three groups and virtually all bile acids were conjugated with taurine. The taurine concentration in liver varied dramatically with the amount of taurine in the diet. Total liver lipid content decreased with increasing dietary taurine. Individual lipid components also varied, especially free fatty acids (which decreased with increasing dietary taurine) and triglycerides (which increased with increasing dietary taurine), indicating that taurine has a metabolic effect on lipid metabolism. Taurine deficiency also caused significant changes in the fatty acid distribution of sphingomyelin. In particular, a decrease of lignoceric acid and an increase of nervonic acid were observed. The present data suggest that hepatocellular levels of taurine can modulate the mobilization of liver lipid stores and the utilization by the liver of circulating free fatty acids. These effects are probably mediated by factors affecting membrane fluidity, such as the ratio of cholesterol to phospholipids, the degree of unsaturation of phospholipids and the changes in sphingomyelin fatty acid composition.

(PDF emailed within 0-6 h: $19.90)

Accession: 002072144

Download citation: RISBibTeXText

PMID: 1765815

DOI: 10.1093/jn/121.10.1522

Related references

Effect of dietary taurine on plasma and blood cell taurine concentrations in cats. Journal of Nutrition 117(11): 1945-1949, 1987

Dietary taurine requirement of cats is determined by microbial degradation of taurine in the gut. Advances in Experimental Medicine and Biology 359: 59-70, 1994

Effects of dietary taurine supplementation on plasma and liver lipids in OVX rats fed calcium-deficient diet. Nutrition Research and Practice 2(1): 13-16, 2008

Gender and dietary amino acid supplementation influence the plasma and whole blood taurine status of taurine-depleted cats. Journal of Nutrition 121(11 Suppl): S173-S174, 1991

The effect of dietary supplementation with cysteic acid on the plasma taurine concentration of cats maintained on a taurine-restricted diet. Advances in Experimental Medicine and Biology 315: 23-32, 1992

Effects of dietary methionine taurine cystine and glycine on liver and serum lipids in rats fed with a histidine excess diet. Agricultural & Biological Chemistry 52(4): 1027-1032, 1988

Effects of dietary taurine and arsenic on plasma and liver mineral content in the spontaneously hypertensive rat. Proceedings of the North Dakota Academy of Science: 4154, 1987

Therapeutic and prophylactic effects of taurine administration on experimental liver injury effect of taurine on lipid per oxide formation and calcium content in liver. Journal of Kyoto Prefectural University of Medicine 91(1): 9-26, 1982

The effect of dietary taurine content on the plasma taurine concentration of the cat. British Journal of Nutrition 66(2): 227-235, 1991

Dietary taurine needs of cats vary with dietary protein quality and concentration. Veterinary Clinical Nutrition 5(2): 18-22, 1998

Influence of dietary cereal and energy content on the accumulation of lipids in the liver in fatty liver-haemorrhagic syndrome in the fowl. Research in Veterinary Science 24(1): 72-76, 1978

Dietary inclusion level and time effects of taurine on broiler performance, meat quality, oxidative status and muscle taurine content. British Poultry Science 55(5): 598-604, 2015

Myocardial taurine concentrations in cats with cardiac disese and in healthy cats fed taurine-modified diets. American journal of veterinary research 53(2): 237-241, 1992