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Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias



Dietary tocotrienols reduce concentrations of plasma cholesterol, apolipoprotein B, thromboxane B2, and platelet factor 4 in pigs with inherited hyperlipidemias



American Journal of Clinical Nutrition 53(4 Suppl): 1042s-1046s



Normolipaemic and genetically hypercholesterolaemic pigs of defined lipoprotein genotype were given a standard diet supplemented with tocotrienol-rich fraction (TRF) 50 micro g/g isolated from palm oil. Hypercholesterolaemic pigs given the TRF supplement showed a 44% decrease in total serum cholesterol, a 60% decrease in low-density lipoprotein cholesterol, and significant decreases in apolipoprotein B (26%), thromboxane-B2 (41%) and platelet factor 4 (PF4; 29%).

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Accession: 002072147

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PMID: 2012015



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