EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers



Dietary vitamin C intake and concentrations in the body fluids and cells of male smokers and nonsmokers



Journal of Nutrition 122(2): 312-316



Inhaled cigarette smoke releases a variety of oxidizing agents. Ascorbic acid is recognized as an important biological antioxidant. To better characterize the antioxidant protective role of ascorbic acid, a comparison of ascorbic acid concentrations in plasma, leukocytes, bronchoalveolar lavage fluid and alveolar macrophages from a homogeneous group of healthy male smokers (n = 10) and nonsmokers (n 14) was investigated. The resulting ascorbic acid contents were (means +/- SD) 91 +/- 25 (n = 10) and 87 +/- 25 (n = 14) micromole/L in plasma, 2.09 +/- 0.62 (n = 7) and 2.12 +/- 0.77 (n = 11) micromole/10(9) cells in mononuclear leukocytes, 3.2 +/- 2.2 (n = 10) and 1.7 +/- 1.5 (n = 13) micromole/L in bronchoalveolar lavage fluid and 3.4 +/- 2.3 (n = 8) and 1.6 +/- 1.3 (n = 6) micromole/10(9) cells in alveolar macrophages from smokers and nonsmokers, respectively. Mean daily dietary vitamin C intake was 116 +/- 68 and 107 +/- 59 mg/d for smokers and nonsmokers, respectively. The ascorbic acid contents of bronchoalveolar lavage [3.9 +/- 1.9 micromole/L (n = 8)] and alveolar macrophages [4.1 +/- 2.1 micromole/10(9) cells (n = 6)] of smokers consuming 15 to 20 cigarettes/d were significantly higher (P < 0.05) than those of nonsmokers. The increased content of ascorbic acid in bronchoalveolar lavage and in alveolar macrophages of smokers compared with nonsmokers may reflect a defensive mechanism against free radical species derived from cigarette smoke.

(PDF same-day service: $19.90)

Accession: 002072159

Download citation: RISBibTeXText

PMID: 1732471

DOI: 10.1093/jn/122.2.312



Related references

Serum levels of vitamin C in relation to dietary and supplemental intake of vitamin C in smokers and nonsmokers. Annals of the New York Academy of Sciences 498: 144-152, 1987

Lymphocyte DNA strand breaks in smokers and nonsmokers are related to vitamin B-6 intake and metabolite concentrations in plasma and urine. FASEB Journal 17(4-5): Abstract No 711 19, March, 2003

Dietary intake of Australian smokers and nonsmokers. Australian and New Zealand Journal of Public Health 21(2): 141-146, 1997

Elimination of cotinine from body fluids: disposition in smokers and nonsmokers. American Journal of Public Health 79(8): 1046-1048, 1989

True and apparent thiocyanate in body fluids of smokers and nonsmokers. Journal of Applied Physiology 8(3): 289-291, 1955

Plasma vitamin C concentrations of smokers are lower than those of nonsmokers. Vitamins (Kyoto) 81(9): 431-432, 2007

Evaluation of antioxidant vitamin intake and lipid peroxidation in smokers and nonsmokers. Clinical Research 41(3): 657A, 1993

Differences in dietary intake between smokers and nonsmokers among Lumbee Indian women in North Carolina. American Journal of Health Promotion 12(2): 94-97, 1997

Potential Association of Urinary N7-(2-Carbamoyl-2-hydroxyethyl) Guanine with Dietary Acrylamide Intake of Smokers and Nonsmokers. Chemical Research in Toxicology 28(1): 43-50, 2016

Concentration of cotinine in body fluids as a measure of nicotine intake by nonsmokers. Rand, M J And K Thurau (Ed ) Icsu (International Council Of Scientific Unions) Press Symposium Series, Vol 9 The Pharmacology Of Nicotine; Satellite Symposium Of The Tenth International Congress Of Pharmacology, Gold Coast, Queensland, Australia, September 4-6, 1987 Xii+418p Irl Press Ltd : Oxford, England, Uk; Washington, D C , Usa Illus Paper 32-33, 1988

Low seminal plasma folate concentrations are associated with low sperm density and count in male smokers and nonsmokers. Fertility & Sterility 75(2): 252-259, February, 2001

Erythrocyte vitamin E and plasma ascorbate concentrations in relation to erythrocyte peroxidation in smokers and nonsmokers: dose response to vitamin E supplementation. American Journal of Clinical Nutrition 65(2): 496-502, 1997

Quantitative relationship between serum levels and dietary intake of vitamin c in smokers and non smokers. Federation Proceedings 44(3): 778, 1985

Cotinine in seminal fluids of smokers, passive smokers and nonsmokers. Le Journal Medical Libanais. Lebanese Medical Journal 45(1): 46-46, 1997

Decreased blood antioxidant capacity and increased lipid peroxidation in young cigarette smokers compared to nonsmokers: Impact of dietary intake. Nutrition Journal 6(): 39-39, 2007