EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Differences in the membrane interaction of scrapie amyloid precursor proteins in normal and scrapie- or Creutzfeldt-Jakob disease-infected brains



Differences in the membrane interaction of scrapie amyloid precursor proteins in normal and scrapie- or Creutzfeldt-Jakob disease-infected brains



Journal of Infectious Diseases 163(3): 488-494



The membrane interaction and hydrophobicity of the normal (PrPC) and infectious isoform (PrPSc/CJD) of scrapie and Creutzfeldt-Jakob disease amyloid precursor proteins was studied. The normal isoform of hamster and human scrapie amyloid precursor protein was found on the microsomal/synaptosomal membranes anchored by the C-terminal glycolipid.

(PDF same-day service: $19.90)

Accession: 002072372

Download citation: RISBibTeXText

PMID: 1671680

DOI: 10.1093/infdis/163.3.488



Related references

Differences in the membrane interaction of scrapie amyloid precursor proteins in normal and scrapie infected or creutzfeldt jakob disease infected brains. Journal of Infectious Diseases 163(3): 488-494, 1991

Scrapie-associated precursor proteins: antigenic relationship between species and immunocytochemical localization in normal, scrapie, and Creutzfeldt-Jakob disease brains. Neurology 40(3 Pt 1): 513-517, 1990

Prion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob disease. FEBS Letters 536(1-3): 61-65, 11 February, 2003

New mutation in scrapie amyloid precursor gene (at codon 178) in Finnish Creutzfeldt-Jakob kindred. Lancet 337(8738): 425-425, 1991

Antibodies to scrapie prion proteins recognize proteins in murine creutzfeldt jakob disease infected brain. Annals Of Neurology: 152-153, 1984

The ultrastructural diversity of scrapie-associated fibrils isolated from experimental scrapie and Creutzfeldt-Jakob disease. Journal of Comparative Pathology 105(4): 377-386, 1991

Mutation in codon 200 of scrapie amyloid precursor gene linked to Creutzfeldt-Jakob disease in Sephardic Jews of Libyan and non-Libyan origin. Lancet 336(8715): 637-638, 1990

Characterization of antisera against scrapie associated fibrils from affected hamster and cross reactivity with scrapie associated fibrils from scrapie affected mice and patients with creutzfeldt jakob disease. Journal of General Virology 66(11): 2471-2478, 1985

Glycosylation and membrane interaction of normal and scrapie prion proteins and the role in scrapie infectivity. Neurobiology of Aging 13(SUPPL 1): S92-S93, 1992

Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia. Lancet 336(8713): 514-515, 1990

Characterization of antisera against scrapie-associated fibrils (SAF) from affected hamster and cross-reactivity with SAF from scrapie-affected mice and from patients with Creutzfeldt-Jakob disease. Journal of General Virology 66: 2471-2478, 1985

The distribution and antigenic properties of scrapie associated proteins in normal scrapie and cjd brains. Neurology 38(3 SUPPL 1): 169, 1988

Rapid detection of Creutzfeldt-Jakob disease and scrapie prion proteins. Neurology 40(1): 110-117, 1990