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Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion



Different responses of trabecular and cortical bone to 1,25(OH)2D3 infusion



American Journal of Physiology 259(5 Pt 1): E715-E722



To determine whether the response of trabecular bone to calcitriol differed from the response of cortical bone, calcitriol was infused into rats, and bone mass, 45Ca accumulation, and the density distribution of bone particles (as a measure of bone maturation) in both the proximal tibia and shaft were examined. In the proximal tibia, calcitriol decreased 45Ca accumulation, yet increased bone mass and shifted the particle distribution to more mineralized fractions.

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Accession: 002072475

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PMID: 2240210



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