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Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis

Differential effects of CD4+ and CD8+ cells in acute, systemic murine candidosis

Journal of Leukocyte Biology 51(3): 305-306

Monoclonal antibody depletion was used to assess contributions of CD4+ and CD8+ cells in resistance to systemic murine Candida albicans infection. Depletion of CD8+ cells did not influence either survival or mean survival time (MST); however, depletion of CD4+ cells significantly enhanced both survival and MST. Combined depletion of both CD4+ and CD8+ cells significantly lengthened the MST but did not enhance survival.

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Accession: 002072568

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PMID: 1347313

DOI: 10.1002/jlb.51.3.305

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