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Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif



Differential expression of the mouse U1a and U1b SnRNA genes is not dependent on sequence differences in the octamer motif



Biochemical Journal 277: 719-722



The mouse U1b SnRNA gene is expressed in only a limited range of cell types, whereas the U1a SnRNA gene is expressed in all cells. These 2 genes differ in the sequence of the octamer motif, which plays a critical role in SnRNA gene regulation. It was shown that the U1b octamer binds the octamer-binding protein Oct-1 with higher affinity than does the U1a octamer in both U1b-expressing and U1b-non-expressing cell lines and tissues.

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Accession: 002072646

Download citation: RISBibTeXText

PMID: 1872807

DOI: 10.1042/bj2770719


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