+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Differential reduction of plasma cholesterol by the American Heart Association Phase 3 Diet in moderately hypercholesterolemic, premenopausal women with different body mass indexes

Differential reduction of plasma cholesterol by the American Heart Association Phase 3 Diet in moderately hypercholesterolemic, premenopausal women with different body mass indexes

American Journal of Clinical Nutrition 55(2): 385-394

The ability of a low-fat, low-cholesterol diet to improve the risk-factor profiles of moderately hypercholesterolemic, premenopausal women was evaluated. Nineteen women were fed a typical American diet for 1 mo, after which a low-fat diet consisting of 21% of total energy (en%) as fat, 59 en% carbohydrates, 19 en% protein, and 96 mg cholesterol/d (P:S 1.8) was given. After 5 months, total and low-density lipoprotein (LDL) cholesterol was decreased by 7% and 11%, respectively, and total triglycerides increased by approximately 30%. High-density-lipoprotein (HDL) cholesterol was decreased by 12% at month 2 and 5% at month 5 (P less than 0.05). Although HDL2 cholesterol decreased progressively throughout the diet period to -35% by month 5, HDL3 cholesterol, which decreased to -5% at month 1, increased to +7% by month 5. Of the plasma apolipoproteins only apo A-II was altered (+15%) by the diet. Body mass index correlated to baseline values and affected response to diet; only the leanest women had significant decreases in total, LDL, and HDL2 cholesterol in response to the low-fat diet.

(PDF emailed within 1 workday: $29.90)

Accession: 002072741

Download citation: RISBibTeXText

PMID: 1734676

Related references

Comparison of 2 dietary fat levels in reducing ldl cholesterol in moderately hypercholesterolemic premenopausal women. Circulation 80(4 SUPPL 2): II104, 1989

Reduction of plasma cholesterol levels in normal men on an American Heart Association Step 1 diet or a Step 1 diet with added monounsaturated fat. New England Journal of Medicine 322(9): 574-579, 1990

Plasma plasminogen activator inhibitor-I is associated with plasma leptin irrespective of body mass index, body fat mass, and plasma insulin and metabolic parameters in premenopausal women. Metabolism, Clinical and Experimental 48(8): 960-964, 1999

Beta-conglycinin deficient in isoflavones and saponins did not lower plasma concentrations of lipoproteins and cholesterol over time in moderately hypercholesterolemic women. FASEB Journal 15(4): A274, March 7, 2001

Differential effect of National Cholesterol Education Program (NCEP) Step II diet on HDL cholesterol, its subfractions, and apoprotein A-I levels in hypercholesterolemic women and men after 1 year: the beFIT Study. Arteriosclerosis, Thrombosis, and Vascular Biology 20(6): 1580-1587, 2000

The cholesterol facts. A summary of the evidence relating dietary fats, serum cholesterol, and coronary heart disease. A joint statement by the American Heart Association and the National Heart, Lung, and Blood Institute. The Task Force on Cholesterol Issues, American Heart Association. Circulation 81(5): 1721-1733, 1990

Orange juice increases plasma HDL cholesterol and reduces the LDL/HDL cholesterol ratio in moderately hypercholesterolemic subjects. Circulation 100(18 SUPPL ): I 824, Nov 2, 1999

Plasma lipid and lipoprotein responsiveness to dietary fat and cholesterol in premenopausal African American and white women. American Journal of Clinical Nutrition 72(1): 56-63, 2000

Transdermal oestradiol lower cholesterol in moderately hypercholesterolemic women. Maturitas 27(SUPPL ): 65-66, 1997

Hydrogenated fat consumption affects cholesterol synthesis in moderately hypercholesterolemic women. Journal of Lipid Research 41(5): 834-839, 2000

Sex hormones in obese premenopausal women and their relationships to body fat mass and distribution, B cell function and diet composition. Journal of Endocrinological Investigation 10(4): 345-350, 1987

Association of Body Mass Index and Age With Subsequent Breast Cancer Risk in Premenopausal Women. JAMA Oncology: E181771-E181771, 2018

Stanol-supplemented margarine lowers LDL-C in moderately hypercholesterolemic subjects fed an average American diet. FASEB Journal 12(4): A206, March 17, 1998

Serum lipids response dietary adherence and nutritional adequacy in hypercholesterolemic subjects on the american heart association step i diet. Journal of the American Geriatrics Society 39(8): A3, 1991

The citrus flavonoids hesperidin and naringin do not affect serum cholesterol in moderately hypercholesterolemic men and women. Journal of Nutrition 140(9): 1615-1620, 2010