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Differentiation of lesions caused by mycotoxin T-2 from autolytic morphologic change in CD-1 mice



Differentiation of lesions caused by mycotoxin T-2 from autolytic morphologic change in CD-1 mice



Journal of Comparative Pathology 103(4): 379-385



Experiments with topically applied T-2 trichothecene mycotoxin were undertaken to determine whether lesions caused by this toxin could be differentiated from autolysis. Two pathologists, who had previously seen lesions caused by T-2 toxin, graded lesions without knowledge of treatment group and stated whether the animal had received the toxin or not. Both pathologists differentiated T-2 toxin-treated mice up to 6 h post-mortem. Failure to distinguish between treated and control mice resulted in false-negative diagnoses only. It was concluded that the diagnosis of trichothecene mycotoxicosis would probably be missed more than 6 h post-mortem.

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Accession: 002072942

Download citation: RISBibTeXText

PMID: 2079553

DOI: 10.1016/s0021-9975(08)80026-6



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