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Effect of exogenous insulin on the metabolism of normal rat



Effect of exogenous insulin on the metabolism of normal rat



Korean Journal of Nutrition 22(4): 237-246



The objective of this study was to determine the metabolic effect of exogenous insulin on Sprague-Dawley rats. In a short-term study, the rats were injected insulin and sacrificed at 0, 0.5, 1, 1.5, 2, 4 and 6hr, respectively. Another group of the rats were injected long-acting insulin everyday and sacrificed at 0, 10, 20 and 30 days, respectively. Levels of hemoglobin, hematocrit, plasma glucose, plasma protein, plasma albumin, plasma lipids, cholesterol were determined for each experimental group. Also microscopic observation of fat infiltration of liver and aorta performed. No significant abnormality was observed either at the short-term or at the long-term insulin injection on normal rats.

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Accession: 002082142

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