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Effect of glutathione administration on starvation induced lipid peroxidation



Effect of glutathione administration on starvation induced lipid peroxidation



Bollettino Societa Italiana di Biologia Sperimentale 66(11): 1097-1104



Male Wistar rats weighing about 200 g with external biliary-duodenal fistulae were starved for 16 h so that reduced glutathione (GSH) was depleted then given GSH or a saline solution 50 mg/kg hourly intraperitoneally during 6 h. In rats given GSH biliary excretion of GSH increased. Excretion of oxidised glutathione (GSSG) decreased. In controls the reverse pattern was observed. Hepatic GSH and GSSG were similar in the 2 groups. Malondialdehyde was greater in liver and plasma of control rats.

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Accession: 002082837

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