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Element lipid correlations in schizophrenia

Element lipid correlations in schizophrenia

Trace Elements in Medicine 8(2): 101-105

In a correlational study of serum elements and plasma lipids in 13 schizophrenic inpatients and 11 controls, the schizophrenic group, which had a higher cardiac risk, had highly significant correlations of scandium and cesium with RBC phospholipids and of indium and bromine with plasma phospholipids. In the control group, strontium and selenium were associated with RBC phospholipids while no element reached a similar level of significance for plasma phospholipids. These interactions may represent different precursors to, and states of, the RBC membrane. In both groups, bromine had positive correlations with the HDL fractions, HDL 2 and HDL 3. Iodine, presumably as a component of thyroxine, correlated with total plasma cholesterol only in the schizophrenic group. Serum rubidium was lower in schizophrenics but divalent cations may be important for specific extra-pyramidal syndromes caused by neuroleptics. Psychiatric consequences of altered cardiac risk may be identified by looking at specific phospholipids or at HDL sub-fractions. Alternatively it may be alteration of relationship with elements which is important.

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