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In vitro solubility of calcium glycerophosphate versus conventional mineral salts in pediatric parenteral nutrition solutions



In vitro solubility of calcium glycerophosphate versus conventional mineral salts in pediatric parenteral nutrition solutions



Journal of Pediatric Gastroenterology and Nutrition 9(1): 67-72



Low-birth-weight infants requiring total parenteral nutrition receive inadequate intakes of calcium (Ca) and phosphorus (P) due to poor solubility of available mineral salts. To optimize Ca/P delivery, we tested the effects on in vitro solubility of mineral salt:calcium glycerophosphate (CaGP) versus calcium gluconate and K2HPO4 (CG + P); Ca:P ratios of 1:1 (at 12.5 and 25 mmol/L of Ca and P) and 2:1 (25:12.5 mmol/L); amino acid (AA) formulation: Aminosyn (A), Aminosyn-PF (A-PF), TrophAmine (T) or Vaminolac (V); and AA concentration (25 versus 8.3 g/L). Parenteral nutrition solutions contained 10% dextrose and vitamins and minerals typical of a neonatal prescription. Solutions were sampled at preparation, after 24 h in the neonatal unit (25.degree. C), and from before and after a 0.22-.mu.m filter in extension tubing through which solutions were pumped at 5 ml/h within an incubator at 37.degree. C. Samples were analyzed for Ca and pH, and precipitation by spectrophotometry at 600 nm and light microscopy at .times. 100 magnification. The Ca concentration was unaffected by filtration. While spectrophotometry detected only gross precipitation, with light microscopy crystal formation was evident with 25 mmol/L of Ca and P as CG + P in A and T at 25 g of AA/L and in A, V, T, and A-PF at 8.3 g of AA/L. Precipitation did not occur with CaGP or CG + P at 12.5 mmol/L of Ca and P. Under in vitro conditions mimicking the neonatal unit, CaGP versus CG + P resulted in greater mineral solubility even at low AA concentrations.

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Accession: 002133701

Download citation: RISBibTeXText

PMID: 2506324

DOI: 10.1097/00005176-198909010-00013


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