+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Infection of SDAV-immune rats with SDAV and rat coronavirus

Infection of SDAV-immune rats with SDAV and rat coronavirus

Laboratory Animal Science 40(4): 363-366

Infection of rats with sialodacryoadenitis virus (SDAV) or rat coronavirus (RCV) is acute and self-limiting, and elimination and control of either virus is based on the assumption that recovered rats are immune to reinfection. To test this hypothesis, we examined whether SDAV-immune rats could be infected with RCV or reinfected with SDAV. Sprague Dawley (SD) rats were inoculated intranasally with SDAV or with culture medium alone and serial SDAV antibody titers were obtained. Eleven months after inoculation, when antibody titers had stabilized, SDAV-immune and nonimmune rats were challenged with SDAV or RCV, and euthanatized 3 or 6 days later. SDAV-immune rats challenged with SDAV or RCV manifested acute rhinitis associated with virus antigen by 3 days after inoculation, but no lesions or antigen were subsequently found in the lower respiratory tract, salivary glands or lacrimal glands. There was also a marked anamnestic increase in antibody titer by 6 days after challenge. SDAV-immune rats challenged with SDAV or RCV also transmitted infection to nonimmune cage mates. This study indicates that 11 months after primary, infection with SDAV, rats can be infected with SDAV or RCV, but that the severity of disease is significantly reduced.

Please choose payment method:

(PDF emailed within 1 workday: $29.90)

Accession: 002135980

Download citation: RISBibTeXText

PMID: 2166861

Related references

Chronic sialodacryoadenitis virus (SDAV) infection in athymic rats. Laboratory Animal Science 41(1): 22-25, 1991

Sequence analysis of the nucleocapsid protein gene of rat coronavirus SDAV-681. Virology 193(1): 520-523, 1993

Transmission of sialodacryoadenitis virus (SDAV) from infected rats to rats and mice through handling, close contact, and soiled bedding. Laboratory Animal Science 42(4): 344-346, 1992

The time course of the immune response to experimental coronavirus infection of man. Epidemiology & Infection 105(2): 435-446, 1990

Coronavirus infection and demyelination. Sequence conservation of the S-gene during persistent infection of Lewis-rats. Advances in Experimental Medicine and Biology 440: 767-773, 1998

The role of the CNS innate immune system in neurotropic coronavirus infection. Journal of Neurovirology 8(Suppl. 1): 58-59, 2002

Influence of the immune system on the course of infection with murine coronavirus JHM in suckling mice. Advances in Experimental Medicine and Biology 142: 375-386, 1981

The mucosal immune response of swine and its relationship to infection with an enteric coronavirus. Dissertation Abstracts International, B 47(6): 2337, 1986

Cellular immune responses to severe acute respiratory syndrome coronavirus (SARS-CoV) infection in senescent BALB/c mice: CD4+ T cells are important in control of SARS-CoV infection. Journal of Virology 84(3): 1289-1301, 2010

Serological evidence of coronavirus infection in mithuns (Bos frontalis) from India FT Confirmation serologique de l'infection a coronavirus chez le gayal (Bos frontalis) en Inde (resume). 2007

Coronavirus infection in mink (Mustela vison). Serological evidence of infection with a coronavirus related to transmissible gastroenteritis virus and porcine epidemic diarrhea virus. Veterinary Microbiology 31(1): 1-10, 1992

Neutrophils are needed for an effective immune response against pulmonary rat coronavirus infection, but also contribute to pathology. Journal of General Virology 95(Pt 3): 578-590, 2014

Intrathecal humoral immune response in coronavirus induced encephalomyelitis of Lewis and BN rats. Advances in Experimental Medicine and Biology 218: 373-381, 1987

Coronavirus jhm induced demyelinating encephalomyelitis in rats analysis of the intrathecal immune response. Journal of Neuroimmunology 16(1): 46-47, 1987