+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Inherited iron overload

Inherited iron overload

Acta Paediatrica Scandinavica. Supplement 361: 86-95

Iron overload may be produced by 3 mechanisms; inappropriately increased mucosal absorption of Fe, parenteral administration or injection of therapeutic Fe and grossly excessive oral intake over long periods. However, several inherited forms of Fe overload have been described, and it is accepted that haemochromatosis (HG) is an inherited disorder. The combination of serum Fe transferrin saturation and serum ferritin measurement will detect Fe overload in an early, precirrhotic stage.

(PDF emailed within 0-6 h: $19.90)

Accession: 002139693

Download citation: RISBibTeXText

PMID: 2485590

DOI: 10.1111/apa.1989.78.s361.86

Related references

Novel genes, proteins, and inherited disorders of iron overload: iron metabolism is less boring than thought. Haematologica 87(2): 115-116, 2002

Iron homeostasis and inherited iron overload disorders: an overview. Hematology/Oncology Clinics of North America 18(6): 1379-403, Ix, 2004

Inherited Disorders of Iron Overload. Frontiers in Nutrition 5: 103-103, 2018

Inherited iron overload disorders. Current Opinion in Pediatrics 12(6): 596-602, 2000

The carbonyl iron rat model of iron overload Studies of neonatal iron overload and hepatic iron loss. Hepatology 16(4 PART 2): 235A, 1992

Toxicity of iron overload and iron overload reduction in the setting of hematopoietic stem cell transplantation for hematologic malignancies. Critical Reviews in Oncology/Hematology 113: 156-170, 2017

The Dysmetabolic iron overload syndrome A concept which unites hepatic iron overload associated with polymetabolic disorders, steatosis, and NASH. Hepatology 28(4 PART 2): 501A, 1998

Liver cirrhosis: gastropathy and iron overload. Iron overload impairs pro-inflammatory cytokine responses by Kupffer cells. Journal of Gastroenterology and Hepatology 16(4): 438-444, 2001

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine β-thalassemia intermedia. Blood 121(7): 1200-1208, 2013

Experimental iron overload using ferric nitrilotriacetate (Fe3+-NTA): a proposal model of the diseases in man caused by iron overload. Nihon Ketsueki Gakkai Zasshi 49(8): 1650-1659, 1986

An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe-/- mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia. 2013

Diagnostic strategy for iron overload in adults (excluding hematologic iron overload). Gastroenterologie Clinique et Biologique 24(5 Pt 2): B88-B89, 2000

Mild iron overload in patients carrying the HFE S65C gene mutation: a retrospective study in patients with suspected iron overload and healthy controls. Gut 51(5): 723-730, 2002

Experimental hepatic iron overload in the baboon: results of a two-year study. Evolution of biological and morphologic hepatic parameters of iron overload. Digestive Diseases and Sciences 28(7): 616-624, 1983

Three kinships with ALAS2 P520L (c. 1559 C --> T) mutation, two in association with severe iron overload, and one with sideroblastic anemia and severe iron overload. Blood Cells, Molecules & Diseases 36(2): 292-297, 2006