+ Site Statistics
+ Search Articles
+ PDF Full Text Service
How our service works
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ Translate
+ Recently Requested

Inhibition of mammary carcinogenesis in rats by dietary restriction



Inhibition of mammary carcinogenesis in rats by dietary restriction



Cancer Letters 40(2): 133-142



Mammary tumors were induced by 7,12-dimethylbenz[a]anthracene (DMBA) in Sprague-Dawley female rats kept under different dietary restrictions. Starting at 40 days of age, 4 groups of rats were either full-fed or fed 25%, 50% or 80% of their daily ration. At 55 days of age DMBA was given by intravenous injection. Rats were continued on the restricted diet until 150 days after carcinogen treatment. Rats on 25% diet lost weight rapidly and the experiment had to be terminated. Rats on the 50% diet maintained a lower body weight throughout the experiment; only 12% developed tumors. Rats on the 80% diet lost weight initially, but at the termination of the experiment, there was no significant difference in body weight between this group and the full-fed controls. Of the rats on 80% diet, 34% developed tumors, compared to 92% tumor incidence in the full-fed controls. Vaginal smears were normal in the animals fed the 80% diet, while some irregularity was observed in the 50% group. Breeding capability in rats on the 80% diet was not affected, since there was no observable difference in the pregnancy rate between these animals and their controls. There was also no difference in plasma level of estrogen between the 80% diet group and the full-fed controls at the time of carcinogen treatment. [3H]Thymidine labelling index was significantly affected by 50% restriction of diet while there was no significant change in the 80% group.

Please choose payment method:






(PDF emailed within 0-6 h: $19.90)

Accession: 002139931

Download citation: RISBibTeXText

PMID: 3133106

DOI: 10.1016/0304-3835(88)90003-1


Related references

Adrenalectomy Does Not Block the Inhibition of Mammary Carcinogenesis by Dietary Energy Restriction in Rats. The Journal of Nutrition 134(5): 1152-1156, 2004

Adrenalectomy does not block the inhibition of mammary carcinogenesis by dietary energy restriction in rats. Journal of Nutrition 134(5): 1152-1156, 2004

Effects of dietary energy repletion and IGF-1 infusion on the inhibition of mammary carcinogenesis by dietary energy restriction. Molecular Carcinogenesis 42(3): 170-176, 2004

Effect of dietary energy restriction on mammary carcinogenesis and on circulating IGF-I and corticosterone in adrenalectomized rats. Proceedings of the American Association for Cancer Research Annual Meeting 44: 174, 2003

Defining the role of histone deacetylases in the inhibition of mammary carcinogenesis by dietary energy restriction (DER): effects of suberoylanilide hydroxamic acid (SAHA) and DER in a rat model. Cancer Prevention Research 6(4): 290-298, 2013

Serum lipid concentrations during 7,12-dimethylbenz -anthracene -induced mammary carcinogenesis of rats fed diets of different types of protein with 20 percent dietary restriction. FASEB Journal 8(4-5): A721, 1994

Elevated expression of P27 in mammary gland by caloric restriction and corticosterone administration Possible role in CR mediated inhibition of mammary carcinogenesis. Proceedings of the American Association for Cancer Research Annual Meeting 39: 115, 1998

Inhibition of chemically induced mammary and colon tumor promotion by caloric restriction in rats fed increased dietary fat. Cancer Research 47(11): 2759-2762, 1987

Effects of dietary fat and energy restriction on rat mammary carcinogenesis. FASEB Journal 2(5): ABSTRACT 5201, 1988

In vivo inhibition of mammary carcinogenesis, formation of DNA-carcinogen adducts, and mammary gland proliferation by dietary dibenzoylmethane. Abstracts of Papers American Chemical Society 221(1-2): AGFD 24, 2001

Effect of dietary energy restriction on vascular density during mammary carcinogenesis. Cancer Research 64(16): 5643-5650, 2004

Effect of IGF-I infusion on mammary carcinogenesis and on circulating IGF-I and corticosterone during dietary energy restriction. Proceedings of the American Association for Cancer Research Annual Meeting 44: 172, 2003

Effect of dietary energy restriction on angiogenesis during chemically-induced mammary carcinogenesis. Proceedings of the American Association for Cancer Research Annual Meeting 44: 951-952, 2003

Very moderate short term calorie restriction abolishes the enhancement of mammary carcinogenesis by dietary fat. Proceedings of the American Association for Cancer Research Annual Meeting 28: 159, 1987

Dietary o-carotene inhibits mammary carcinogenesis in rats depending on dietary l-linolenic acid content. British journal of nutrition 96(1): 18-21, 2006