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Sequence instability and functional inactivation of murine Y chromosomes can occur on a specific genetic background

Sequence instability and functional inactivation of murine Y chromosomes can occur on a specific genetic background

Molecular Biology and Evolution 9(2): 331-365

When the Y chromosome from Mus poschiavinus (YPos) is backcrossed onto the C57BL/6J laboratory strain of mice, testicular dysfunction occurs at a high frequency. When 5 multicopy probes from the recombinationally suppressed region of the Y chromosome were used in the present work, genomic DNAs from sibling progeny of C57BL/6J YPos were found to contain YPos-specific sequences ranging from trace levels to levels consistent with an intact Y chromosome.

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Accession: 002219012

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PMID: 1560768

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