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Sequential chromosomal alterations in rat liver epithelial cells during aflatoxin-induced neoplastic transformation in vitro

Sequential chromosomal alterations in rat liver epithelial cells during aflatoxin-induced neoplastic transformation in vitro

Journal of Toxicology, Toxin Reviews 8(1-2): 195-215

Chromosomal changes in liver epithelial cells undergoing aflatoxin B1 (AFB1) induced transformation were studied in 2 well-characterized epithelial cell cultures derived from rat liver. Diploid liver cells, which did not possess any in vitro transformation marker or the ability to induce tumours in vivo, were treated with AFB1 and the karyotypes were analysed sequentially at regular intervals.

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Accession: 002219144

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DOI: 10.3109/15569548909059750

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