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Sequestrian of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme disease



Sequestrian of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme disease



Lancet British edition 335(8685): 312-315



To find out whether apparent seronegativity in patients strongly suspected of having Lyme disease can be due to sequestration of antibodies in immune complexes, such complexes were isolated and tested for antibody to B. burgdorferi. In a blinded analysis, the antibody was detected in all 10 seronegative Lyme disease patients with erythema chronicum migrans (ECM), in none of 19 patients with other diseases, and in 4 of 12 seronegative patients who probably had Lyme disease but had no ECM.

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Accession: 002219190

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