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Serotonin in early onset, male alcoholics with violent behaviour

Serotonin in early onset, male alcoholics with violent behaviour

Annals of Medicine 22(5): 327-331

Several lines evidence suggest that abnormal brain serotonin metabolism may occur in early onset, type 2 alcoholism in men. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration has been found to be associated with a history of paternal alcoholism, and abnormal oral glucose tolerance tests (tendency to low blood glucose nadir) in subjects who are prone to exhibit impulsive, aggressive behaviour under the influence of alcohol. Moreover, a low ratio of the concentrations of tryptophan and other large neutral amino acids in plasma seems to correlate with early onset alcohol abuse and violent tendencies. More knowledge is required about neurochemical changes in homogeneous subgroups of alcoholics such as the putative type 2 so as to understand which of the relationships are causative and to provide treatment strategies for alcoholism and its complications.

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Accession: 002219618

Download citation: RISBibTeXText

PMID: 2291840

DOI: 10.3109/07853899009147915

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