EurekaMag.com logo
+ Site Statistics
References:
53,623,987
Abstracts:
29,492,080
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Serotonin precursor influenced by type of carbohydrate meal in healthy adults



Serotonin precursor influenced by type of carbohydrate meal in healthy adults



American Journal of Clinical Nutrition 47(3): 433-439



We compared the effects on the ratio of plasma tryptophan to large neutral amino acids (trp:LNAA) of two different carbohydrate meals (sucrose or starch, 120 g) and a contrasting meal of fat + protein given at breakfast to 10 healthy adults. Plasma glucose and insulin were also measured. The trp:LNAA ratio rose after both carbohydrate meals (p less than 0.001). Glucose and insulin peaks were higher after sucrose than starch, and trp:LNAA rose correspondingly higher (sucrose +34% and starch +20%, p less than 0.05). The ratio declined 45% after the fat + protein meal. A 180 min, absolute ratio values were twofold higher after carbohydrate (sucrose 0.133 and starch 0.127) than after fat + protein (0.057). Similar results were found with the same meals given in the evening. Our results suggest that high-carbohydrate meals have an influence on serotonin synthesis. We predict that carbohydrates with a high glycemic index would have a greater serotoninergic effect than carbohydrates with a low glycemic index.(author)

(PDF same-day service: $19.90)

Accession: 002219622

Download citation: RISBibTeXText

PMID: 3279747

DOI: 10.1093/ajcn/47.3.433



Related references

Type of carbohydrate meal and serotonin precursor in healthy adults. Proceedings of the Nutrition Society of Australia 11: 101, 1986

A carbohydrate meal attenuates the forearm vasoconstrictor response to lower body subatmospheric pressure in healthy young adults. Clinical Autonomic Research 7(6): 285-291, 1998

Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study. Nutrition & Metabolism 6: 52-52, 2009

Carbohydrate Counting at Meal Time Followed by a Small Secondary Postprandial Bolus Injection at 3 Hours Prevents Late Hyperglycemia, Without Hypoglycemia, After a High-Carbohydrate, High-Fat Meal in Type 1 Diabetes. Diabetes Care 39(9): E141-E142, 2016

Postprandial glycemic response with identical carbohydrate meal amounts in type I diabetic patients treated with short-acting insulin analogs compared to healthy subjects. Journal of the Japan Diabetes Society 50(6): 379-384, 2007

Is the gastrocolonic response influenced by fat or carbohydrate content of a meal?. Gastroenterology 110(4 SUPPL ): A742, 1996

Lack of association between the serotonin transporter and serotonin 1A receptor: an in vivo PET imaging study in healthy adults. Psychiatry Research 255: 81-86, 2016

Gastric emptying and intestinal absorption of carbohydrate and protein as influenced by the nature of the test meal. Journal of Nutrition 66(1): 91-103, 1958

Better cognitive performance following a low-glycaemic-index compared with a high-glycaemic-index carbohydrate meal in adults with type 2 diabetes. Diabetologia 49(5): 855-862, 2006

Binding of [(3)H]lysergic acid diethylamide to serotonin 5-HT(2A) receptors and of [(3)H]paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults. Neuropsychobiology 40(4): 183-187, 1999

Binding of (3H)lysergic acid diethylamide to serotonin 5-HT2A receptors and of (3H)paroxetine to serotonin uptake sites in platelets from healthy children, adolescents and adults. Neuropsychobiology 40(4): 183-187, 1999

A simple meal plan of 'eating vegetables before carbohydrate' was more effective for achieving glycemic control than an exchange-based meal plan in Japanese patients with type 2 diabetes. Asia Pacific Journal of Clinical Nutrition 20(2): 161-168, 2011

Substrate Utilization is Influenced by Acute Dietary Carbohydrate Intake in Active, Healthy Females. Journal of Sports Science & Medicine 10(1): 59-65, 2011

Effect of a purified amylase inhibitor on carbohydrate metabolism after a mixed meal in healthy humans. Mayo Clinic Proceedings 62(4): 249-255, 1987

Effect of increased amounts of pectin in a solid liquid meal on carbohydrate metabolism in healthy man. Gastroenterologie Clinique et Biologique 12(6-7): 559-564, 1988