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Serum IgG from CBA/K1Jms-lprcgmice induces interleukin 3 in an interleukin-3-dependent cell line - possible correlation with lymphadenopathy



Serum IgG from CBA/K1Jms-lprcgmice induces interleukin 3 in an interleukin-3-dependent cell line - possible correlation with lymphadenopathy



Cellular Immunology 138(2): 372-380



Serum IgG of CBA-K1Jms-lprcg/lprcg mice with spontaneous systemic lymphadenopathy supported the proliferation of an interleukin-3 (IL-3)-dependent cell line, FDC-P2/185-4. The lprcg/lprcg IgG induced IL-3 synthesis in FDC-P2/185-4 cells, and cells grew by an autocrine mechanism. There was virtually no time lag between the appearance of lymphadenopathy and the increase in IL-3-inducing activity in the serum.

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Accession: 002219676

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