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Serum antibodies of dogs suffering from autoimmune disorders which recognize a 40 kD glycoprotein in the nucleus of mammalian cells



Serum antibodies of dogs suffering from autoimmune disorders which recognize a 40 kD glycoprotein in the nucleus of mammalian cells



Comptes Rendus de l' Academie des Sciences Series 3, Sciences de la Vie 311(4): 137-142



Characterization of a new autoantibody is characterized from the sera of 15 dogs with systemic lupus erythematosus or clinically related disorders is described. The antibody produces a speckled immunofluorescent staining of the nucleus, excluding the nucleolus, of human Hep-2 cells. Immunodiffusion tests with saline extracts of rabbit thymus revealed a precipitation line which crosses lines from reference sera to 5m, RNP, SS-BLa, and SS-A/ro antigens.

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Accession: 002219704

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