+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Serum beta-carotene before and after beta-carotene supplementation

Serum beta-carotene before and after beta-carotene supplementation

European Journal of Clinical Nutrition 46(1): 15-24

A two-month double-blind, placebo-controlled supplementation study of oral beta-carotene (20 mg daily) was conducted. Two hundred and twenty two 30-69 year old men were randomized into either a beta-carotene or placebo group, and serum samples were obtained at baseline, follow-up (2 months), and up to 12 weeks post-supplementation. Serum beta-carotene increased on average 10-fold in the beta-carotene group, from 0.53 +/- 0.32 micromole/l (mean +/- SD) at baseline to 4.99 +/- 2.47 micromole/l at follow-up (P < 0.0001), and beta-carotene levels remained elevated up to 12 weeks post-supplementation (0.61 +/- 0.15 micromole/l). No changes in serum retinol, alpha-tocopherol, or total cholesterol were observed. At baseline, serum beta-carotene levels were positively correlated with dietary beta-carotene (r = 0.29) and inversely correlated with body mass index and serum gamma-glutamyltransferase (r = -0.33 and r = -0.40, respectively). The inverse association with body mass index and serum gamma-glutamyltransferase persisted during active supplementation, whereas the positive association with dietary beta-carotene disappeared. In multivariate analysis, serum cholesterol was also positively associated with serum beta-carotene levels both before and after supplementation. Baseline serum beta-carotene was the factor most strongly associated (positively) with serum beta-carotene after supplementation. Our study highlights the importance of several factors which affect serum beta-carotene.

(PDF 0-2 workdays service: $29.90)

Accession: 002219714

Download citation: RISBibTeXText

PMID: 1348473

Related references

Kinetics of the response of milk and serum beta-carotene to daily beta-carotene supplementation in healthy, lactating women. American Journal of Clinical Nutrition 67(2): 276-283, 1998

Low-dose beta-carotene supplementation and deworming improve serum vitamin A and beta-carotene concentrations in preschool children of Bangladesh. Journal of Health, Population, and Nutrition 28(3): 230-237, 2010

Serum beta-carotene response to supplementation with raw carrots, carrot juice or purified beta-carotene in healthy non-smoking women. Nutrition Research 16(4): 565-575, 1996

Distribution of beta-carotene and vitamin A in lipoprotein fractions of ferret serum. Effect of beta-carotene supplementation. Annals of the New York Academy of Sciences 691: 232-237, 1993

Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplementation. Nutrition Research 19(3): 381-388, 1999

Supplementation with beta-carotene increases both serum and colonic mucosal concentrations of beta-carotene in humans. Clinical Research 41(3): 645A, 1993

The effect of beta -carotene supplementation on beta -carotene-, retinoid- and malondialdehyde-concentrations of blood serum and liver in Japanese quail (Coturnix coturnix japonica). Magyar Allatorvosok Lapja 122(1): 24-28, 2000

Zinc plus beta-carotene supplementation of pregnant women is superior to beta-carotene supplementation alone in improving vitamin A status in both mothers and infants. American Journal of Clinical Nutrition 80(5): 1299-1307, 2004

Intestinal beta-carotene absorption and cleavage in men: response of beta-carotene and retinyl esters in the triglyceride-rich lipoprotein fraction after a single oral dose of beta-carotene. American Journal of Clinical Nutrition 62(1): 110-116, 1995

An improved hplc method for the separation of fourteen carotenoids including 15 cis beta carotene 13 cis beta carotene and 9 cis beta carotene isomers phytoene and phytofluene. Journal of Liquid Chromatography 14(13): 2457-2476, 1991

Simultaneous dietary supplementation of sodium cholate and beta-carotene markedly enhances accumulation of beta-carotene in mice. Journal of Nutrition 125(12): 3081-3086, 1995

The effect of beta carotene supplementation on the beta carotene and vitamin A levels of blood plasma and some fertility indices of dairy cows. Archiv für Tierernahrung 35(8): 563-570, 1985

No effect of beta-carotene supplementation on risk of nonmelanoma skin cancer among men with low baseline plasma beta-carotene. Cancer Epidemiology, Biomarkers & Prevention 13(6): 1079-1080, 2004