+ Site Statistics
References:
52,654,530
Abstracts:
29,560,856
PMIDs:
28,072,755
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn
+ Translate
+ Recently Requested

Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states



Serum levels of tumour necrosis factor-alpha and interleukin-1 beta during leprosy reactional states



Clinical and Experimental Immunology 84(1): 103-108



The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumor necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of the presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated concentrations of TNF and IL-1 in at least one of the serum samples tested. This included all four patients undergoing type I reversal reaction and nine (50%) of the ENL patients studied. Concentrations of TNF above 1000 pg/ml were found in four patients with ENL. Development of erythema multiforme in these ENL patients represented an aggravating factor and all four patients suffering from this type of lesion demonstrated increased serum TNF levels. All BT patients tested presented elevated IL-1 levels, while only half of them presented elevated levels of TNF. No correlation was found between any particular systemic symptoms and the levels of TNF and IL-1. These results suggest that TNF and IL-1 may be implicated in leprosy reactions, either acting directly or in synergism with other cytokines.

(PDF emailed within 1 workday: $29.90)

Accession: 002219794

Download citation: RISBibTeXText

PMID: 2015700


Related references

Serum levels of interferon-gamma, tumour necrosis factor-alpha, soluble interleukin-6R and soluble cell activation markers for monitoring response to treatment of leprosy reactions. Clinical and Experimental Immunology 150(2): 210-216, 2007

Cerebrospinal fluid and serum protein levels of tumour necrosis factor-alpha (TNF-alpha) interleukin-6 (IL-6) and soluble interleukin-6 receptor (sIL-6R gp80) in multiple sclerosis patients. Cytokine 20(2): 86-89, 2002

Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma. Cancer Letters 95(1-2): 207-212, 1995

Serum levels of interleukin 1beta, interleukin 8 and tumour necrosis factor alpha as markers of gastric cancer. Biomarkers 11(2): 184-193, 2006

Serum levels and gene expressions of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in human renal cell carcinomas. Nihon Hinyokika Gakkai Zasshi. Japanese Journal of Urology 85(4): 563-570, 1994

Serum interleukin-2, interleukin-6, tumour necrosis factor-alpha and nitric oxide levels in patients with Behcet's disease. Annals of the Academy of Medicine, Singapore 33(5): 596-599, 2004

Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients. American Journal of Tropical Medicine and Hygiene 48(3): 324-331, 1993

Influence of tumour necrosis factor-alpha, tumour necrosis factor-beta and interferon-gamma, separately and added together with interleukin-1 beta, on the function of cultured human thyroid cells. Journal of Endocrinology 143(2): 359-365, 1994

Expression of macrophage colony-stimulating factor (M-CSF), interleukin-6, (IL-6), interleukin-1 beta (IL-1 beta), interleukin-11 (IL-11) and tumour necrosis factor-alpha (TNF-alpha) in p53-characterised human ovarian carcinomas. European Journal of Cancer 33(13): 2246-2251, 1998

The effects of Guizhishaoyaozhimu Decoction on serum activity of tumour necrosis factor- alpha (TNF- alpha ) and interleukin 1 beta (IL-1 beta ) in rats with type II collagen induced arthritis. 2005