+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
Most Shared
PDF Full Text
+ PDF Full Text
Request PDF Full Text
+ Follow Us
Follow on Facebook
Follow on Twitter
Follow on LinkedIn

+ Translate
+ Recently Requested

Serum lipoprotein profile in children with celiac disease

Serum lipoprotein profile in children with celiac disease

Journal of Pediatric Gastroenterology and Nutrition 11(1): 58-62

Jejunal mucosa is responsible for the absorption of triglycerides and the production of lipoproteins [chylomicrons, very-low-density lipoprotein (VLDL), high-density lipoprotein (HDL)] and apolipoproteins (B-48, A-I, A-II, A-IV, C-II). Mucosal damage is known to cause fat malabsorption and probably also affects the serum lipid profile. To determine lipoprotein production in states of enterocyte dysfunction, we compared the serum lipid profiles in a group of 12 children with untreated celiac disease (flat jejunal mucosa) with the profiles in a control group of 10 children suffering from other intestinal diseases. Statistically significant differences were found in the following parameters (celiac versus control): plasma levels of triglycerides (70 versus 119 mg/dl), cholesterol content in LDL (107 versus 67.7 mg/dl), protein content in VLDL (6 versus 10 mg/dl), and level of apoprotein A-I (112 versus 140 mg/dl). No significant differences were found between the two groups in the serum levels of total cholesterol, the cholesterol content in VLDL and HDL, the protein content in LDL and HDL, and the level of apoprotein B. Following institution of a gluten-free diet, the lipoprotein profile reverted to normal. These data suggest that the changes in the serum lipoprotein profile in celiac disease are secondary to alterations in enterocyte function and not only a reflection of fat malabsorption.

(PDF emailed within 0-6 h: $19.90)

Accession: 002219816

Download citation: RISBibTeXText

PMID: 2388134

DOI: 10.1097/00005176-199007000-00012

Related references

Serum lipoprotein profile in Algerian patients with celiac disease. Clinica Chimica Acta 235(2): 189-196, 1995

Serum and intestinal celiac disease-associated antibodies in children with celiac disease younger than 2 years of age. Journal of Pediatric Gastroenterology and Nutrition 50(1): 43-48, 2010

A genetic study of celiac disease; incidence of celiac disease, gastrointestinal disorders, and diabetes in pedigrees of children with celiac disease. A.M.A. Journal of Diseases of Children 91(2): 131-137, 1956

Low-serum high-density lipoprotein-cholesterol concentration as a sign of celiac disease. American Journal of Gastroenterology 95(11): 3331-3332, 2000

Gastrointestinal peptide profile in children with celiac disease. Journal of Pediatric Gastroenterology and Nutrition 6(3): 341-345, 1987

Clinical and nutritional profile of children with celiac disease. Indian Pediatrics 40(4): 337-342, 2003

Demographic profile of children diagnosed with celiac disease. American Journal of Gastroenterology 102(Suppl. 2): S553, 2007

Serum lipoprotein profile in Japanese obese children. International Journal of Obesity 6(4): 399-404, 1982

Elevated levels of serum antibodies to the lectin wheat germ agglutinin in celiac children lend support to the gluten-lectin theory of celiac disease. Pediatric Allergy and Immunology 6(2): 98-102, 1995

Effects of a gluten-free diet on serum lipids and lipoprotein (a) levels in a group of patients with celiac disease. Journal of Pediatric Gastroenterology and Nutrition 18(2): 183-185, 1994

Immunogenetic Profile In Children With Celiac Disease The Uzbek Population. Eksperimental'naia i Klinicheskaia Gastroenterologiia 8): 9-12, 2016

Profile of typical and atypical celiac disease in Serbian children. Indian Pediatrics 50(11): 1061-1062, 2014

The baseline serum lipoprotein profile is related to plant stanol induced changes in serum lipoprotein cholesterol and triacylglycerol concentrations. Journal of the American College of Nutrition 27(1): 117-126, 2008

Serum fatty acid profile in celiac disease patients before and after a gluten-free diet. Scandinavian Journal of Gastroenterology 44(7): 826-830, 2010

Serum lipid and lipoprotein profile in children with iron deficiency anemia. Pediatrics International 41(2): 168-173, April, 1999