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Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis



Serum tumor necrosis factor levels and disease dissemination in leprosy and leishmaniasis



Journal of Infectious Diseases 161(5): 988-991



It has been suggested that tumor necrosis factor alpha (TNF.alpha.) may serve as an important antigen-independent host defense mechanism against parasitic organisms. Sera from 66 patients with leishmaniasis and 68 patients with leprosy, all from Ethiopia, were tested for TNF.alpha. using an enzyme-linked immunoassay. Sera from patients with the multi-parasitic/bacillary type of disease (visceral or diffuse cutaneous leishmaniasis and lepromatous leprosy), known to be associated with absent or low specific T cell response, contained significantly higher TNF.alpha. titers than those of patients with pauci-parasitic/bacillary disease (localized cutaneous leishmaniasis and nonlepromatous leprosy). High titers of TNF.alpha. in the absence of a functioning T cell response do not appear to confer resistance against Leishmania aethiopica and Mycobacterium leprae.

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Accession: 002219879

Download citation: RISBibTeXText

PMID: 2324549

DOI: 10.1093/infdis/161.5.988


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